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Discovery of a potent, metabolically stabilized resorcylic lactone as an anti-inflammatory lead.
Bioorg Med Chem Lett. 2009 Nov 1;19(21):6196-9. doi: 10.1016/j.bmcl.2009.08.096. Epub 2009 Sep 3.
Bioorg Med Chem Lett. 2009.
PMID: 19783437
Discovery of an in vitro and in vivo potent resorcylic lactone analog of LL-Z1640-2 as anti-inflammatory lead, II.
Shen Y, Du H, Kotake M, Matsushima T, Goto M, Shirota H, Gusovsky F, Li X, Jiang Y, Schiller S, Spyvee M, Davis H, Zhang Z, Pelletier R, Ikemori-Kawada M, Kawakami Y, Inoue A, Wang Y.
Shen Y, et al. Among authors: spyvee m.
Bioorg Med Chem Lett. 2010 May 15;20(10):3047-9. doi: 10.1016/j.bmcl.2010.03.119. Epub 2010 Apr 9.
Bioorg Med Chem Lett. 2010.
PMID: 20427182
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A novel antagonist of the prostaglandin E(2) EP(4) receptor inhibits Th1 differentiation and Th17 expansion and is orally active in arthritis models.
Chen Q, Muramoto K, Masaaki N, Ding Y, Yang H, Mackey M, Li W, Inoue Y, Ackermann K, Shirota H, Matsumoto I, Spyvee M, Schiller S, Sumida T, Gusovsky F, Lamphier M.
Chen Q, et al. Among authors: spyvee m.
Br J Pharmacol. 2010 May;160(2):292-310. doi: 10.1111/j.1476-5381.2010.00647.x.
Br J Pharmacol. 2010.
PMID: 20423341
Free PMC article.
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Toll-like receptor 2 antagonists. Part 1: preliminary SAR investigation of novel synthetic phospholipids.
Spyvee MR, Zhang H, Hawkins LD, Chow JC.
Spyvee MR, et al.
Bioorg Med Chem Lett. 2005 Dec 15;15(24):5494-8. doi: 10.1016/j.bmcl.2005.08.080. Epub 2005 Oct 19.
Bioorg Med Chem Lett. 2005.
PMID: 16236498
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Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo.
Lamphier M, Zheng W, Latz E, Spyvee M, Hansen H, Rose J, Genest M, Yang H, Shaffer C, Zhao Y, Shen Y, Liu C, Liu D, Mempel TR, Rowbottom C, Chow J, Twine NC, Yu M, Gusovsky F, Ishizaka ST.
Lamphier M, et al. Among authors: spyvee m.
Mol Pharmacol. 2014 Mar;85(3):429-40. doi: 10.1124/mol.113.089821. Epub 2013 Dec 16.
Mol Pharmacol. 2014.
PMID: 24342772
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Evaluation of a candidate anti-arthritic drug using the mouse collagen antibody induced arthritis model and clinically relevant biomarkers.
Bender AT, Spyvee M, Satoh T, Gershman B, Teceno T, Burgess L, Kumar V, Wu Y, Yang H, Ding Y, Akare S, Chen Q.
Bender AT, et al. Among authors: spyvee m.
Am J Transl Res. 2013;5(1):92-102. Epub 2013 Jan 21.
Am J Transl Res. 2013.
PMID: 23390569
Free PMC article.
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Tubulin-based antimitotic mechanism of E7974, a novel analogue of the marine sponge natural product hemiasterlin.
Kuznetsov G, TenDyke K, Towle MJ, Cheng H, Liu J, Marsh JP, Schiller SE, Spyvee MR, Yang H, Seletsky BM, Shaffer CJ, Marceau V, Yao Y, Suh EM, Campagna S, Fang FG, Kowalczyk JJ, Littlefield BA.
Kuznetsov G, et al. Among authors: spyvee mr.
Mol Cancer Ther. 2009 Oct;8(10):2852-60. doi: 10.1158/1535-7163.MCT-09-0301.
Mol Cancer Ther. 2009.
PMID: 19825803
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