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Halogen substituents on the aromatic moiety of the tetracaine scaffold improve potency of cyclic nucleotide-gated channel block.
Bioorg Med Chem Lett. 2011 Nov 1;21(21):6417-9. doi: 10.1016/j.bmcl.2011.08.092. Epub 2011 Aug 27.
Bioorg Med Chem Lett. 2011.
PMID: 21944857
Free PMC article.
Cyclic nucleotide-gated channel block by hydrolysis-resistant tetracaine derivatives.
Andrade AL, Melich K, Whatley GG, Kirk SR, Karpen JW.
Andrade AL, et al. Among authors: melich k.
J Med Chem. 2011 Jul 14;54(13):4904-12. doi: 10.1021/jm200495g. Epub 2011 Jun 14.
J Med Chem. 2011.
PMID: 21634421
Free PMC article.
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Dutasteride and bicalutamide in patients with hormone-refractory prostate cancer: the Therapy Assessed by Rising PSA (TARP) study rationale and design.
Sartor O, Gomella LG, Gagnier P, Melich K, Dann R.
Sartor O, et al. Among authors: melich k.
Can J Urol. 2009 Oct;16(5):4806-12.
Can J Urol. 2009.
PMID: 19796455
Clinical Trial.
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