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Molecular basis for the thiol sensitivity of insulin-degrading enzyme.
Neant-Fery M, Garcia-Ordoñez RD, Logan TP, Selkoe DJ, Li L, Reinstatler L, Leissring MA. Neant-Fery M, et al. Among authors: leissring ma. Proc Natl Acad Sci U S A. 2008 Jul 15;105(28):9582-7. doi: 10.1073/pnas.0801261105. Epub 2008 Jul 8. Proc Natl Acad Sci U S A. 2008. PMID: 18621727 Free PMC article.
Designed inhibitors of insulin-degrading enzyme regulate the catabolism and activity of insulin.
Leissring MA, Malito E, Hedouin S, Reinstatler L, Sahara T, Abdul-Hay SO, Choudhry S, Maharvi GM, Fauq AH, Huzarska M, May PS, Choi S, Logan TP, Turk BE, Cantley LC, Manolopoulou M, Tang WJ, Stein RL, Cuny GD, Selkoe DJ. Leissring MA, et al. PLoS One. 2010 May 7;5(5):e10504. doi: 10.1371/journal.pone.0010504. PLoS One. 2010. PMID: 20498699 Free PMC article.
Accelerated lipofuscinosis and ubiquitination in granulin knockout mice suggest a role for progranulin in successful aging.
Ahmed Z, Sheng H, Xu YF, Lin WL, Innes AE, Gass J, Yu X, Wuertzer CA, Hou H, Chiba S, Yamanouchi K, Leissring M, Petrucelli L, Nishihara M, Hutton ML, McGowan E, Dickson DW, Lewis J. Ahmed Z, et al. Am J Pathol. 2010 Jul;177(1):311-24. doi: 10.2353/ajpath.2010.090915. Epub 2010 Jun 3. Am J Pathol. 2010. PMID: 20522652 Free PMC article.
Identification of BACE2 as an avid ß-amyloid-degrading protease.
Abdul-Hay SO, Sahara T, McBride M, Kang D, Leissring MA. Abdul-Hay SO, et al. Among authors: leissring ma. Mol Neurodegener. 2012 Sep 17;7:46. doi: 10.1186/1750-1326-7-46. Mol Neurodegener. 2012. PMID: 22986058 Free PMC article.
66 results