Nickell JR - Search Results

1

Lobelane inhibits methamphetamine-evoked dopamine release via inhibition of the vesicular monoamine transporter-2.

Nickell JR, Krishnamurthy S, Norrholm S, Deaciuc G, Siripurapu KB, Zheng G, Crooks PA, Dwoskin LP. Nickell JR, et al. J Pharmacol Exp Ther. 2010 Feb;332(2):612-21. doi: 10.1124/jpet.109.160275. Epub 2009 Oct 23. J Pharmacol Exp Ther. 2010. PMID: 19855096 Free PMC article.

2

Pyrrolidine analogues of lobelane: relationship of affinity for the dihydrotetrabenazine binding site with function of the vesicular monoamine transporter 2 (VMAT2).

Vartak AP, Nickell JR, Chagkutip J, Dwoskin LP, Crooks PA. Vartak AP, et al. Among authors: nickell jr. J Med Chem. 2009 Dec 10;52(23):7878-82. doi: 10.1021/jm900770h. J Med Chem. 2009. PMID: 19691331 Free PMC article.

3

The novel pyrrolidine nor-lobelane analog UKCP-110 [cis-2,5-di-(2-phenethyl)-pyrrolidine hydrochloride] inhibits VMAT2 function, methamphetamine-evoked dopamine release, and methamphetamine self-administration in rats.

Beckmann JS, Siripurapu KB, Nickell JR, Horton DB, Denehy ED, Vartak A, Crooks PA, Dwoskin LP, Bardo MT. Beckmann JS, et al. Among authors: nickell jr. J Pharmacol Exp Ther. 2010 Dec;335(3):841-51. doi: 10.1124/jpet.110.172742. Epub 2010 Aug 30. J Pharmacol Exp Ther. 2010. PMID: 20805303 Free PMC article.

4

Phenyl ring-substituted lobelane analogs: inhibition of [³H]dopamine uptake at the vesicular monoamine transporter-2.

Nickell JR, Zheng G, Deaciuc AG, Crooks PA, Dwoskin LP. Nickell JR, et al. J Pharmacol Exp Ther. 2011 Mar;336(3):724-33. doi: 10.1124/jpet.110.172882. Epub 2010 Sep 28. J Pharmacol Exp Ther. 2011. PMID: 20876747 Free PMC article.

5

Tetrabenazine inhibition of monoamine uptake and methamphetamine behavioral effects: locomotor activity, drug discrimination and self-administration.

Meyer AC, Horton DB, Neugebauer NM, Wooters TE, Nickell JR, Dwoskin LP, Bardo MT. Meyer AC, et al. Among authors: nickell jr. Neuropharmacology. 2011 Sep;61(4):849-56. doi: 10.1016/j.neuropharm.2011.05.033. Epub 2011 Jun 12. Neuropharmacology. 2011. PMID: 21669212 Free PMC article.

6

Exploring the effect of N-substitution in nor-lobelane on the interaction with VMAT2: discovery of a potential clinical candidate for treatment of methamphetamine abuse.

Zheng G, Horton DB, Penthala NR, Nickell JR, Culver JP, Deaciuc AG, Dwoskin LP, Crooks PA. Zheng G, et al. Among authors: nickell jr. Medchemcomm. 2013 Mar;4(3):564-568. doi: 10.1039/C3MD20374C. Medchemcomm. 2013. PMID: 23527317 Free PMC article.

7

Pyrrolidine analogs of GZ-793A: synthesis and evaluation as inhibitors of the vesicular monoamine transporter-2 (VMAT2).

Penthala NR, Ponugoti PR, Nickell JR, Deaciuc AG, Dwoskin LP, Crooks PA. Penthala NR, et al. Among authors: nickell jr. Bioorg Med Chem Lett. 2013 Jun 1;23(11):3342-5. doi: 10.1016/j.bmcl.2013.03.092. Epub 2013 Apr 2. Bioorg Med Chem Lett. 2013. PMID: 23597792 Free PMC article.

8

Potential therapeutic uses of mecamylamine and its stereoisomers.

Nickell JR, Grinevich VP, Siripurapu KB, Smith AM, Dwoskin LP. Nickell JR, et al. Pharmacol Biochem Behav. 2013 Jul;108:28-43. doi: 10.1016/j.pbb.2013.04.005. Epub 2013 Apr 18. Pharmacol Biochem Behav. 2013. PMID: 23603417 Free PMC article. Review.

9

GZ-793A, a lobelane analog, interacts with the vesicular monoamine transporter-2 to inhibit the effect of methamphetamine.

Horton DB, Nickell JR, Zheng G, Crooks PA, Dwoskin LP. Horton DB, et al. Among authors: nickell jr. J Neurochem. 2013 Oct;127(2):177-86. doi: 10.1111/jnc.12371. Epub 2013 Aug 19. J Neurochem. 2013. PMID: 23875622 Free PMC article.

10

Synthesis and evaluation of novel azetidine analogs as potent inhibitors of vesicular [3H]dopamine uptake.

Ding D, Nickell JR, Deaciuc AG, Penthala NR, Dwoskin LP, Crooks PA. Ding D, et al. Among authors: nickell jr. Bioorg Med Chem. 2013 Nov 1;21(21):6771-7. doi: 10.1016/j.bmc.2013.08.001. Epub 2013 Aug 11. Bioorg Med Chem. 2013. PMID: 23993667 Free PMC article.

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