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Expression of TGF-beta signaling factors in invasive breast cancers: relationships with age at diagnosis and tumor characteristics.
Figueroa JD, Flanders KC, Garcia-Closas M, Anderson WF, Yang XR, Matsuno RK, Duggan MA, Pfeiffer RM, Ooshima A, Cornelison R, Gierach GL, Brinton LA, Lissowska J, Peplonska B, Wakefield LM, Sherman ME. Figueroa JD, et al. Among authors: flanders kc. Breast Cancer Res Treat. 2010 Jun;121(3):727-35. doi: 10.1007/s10549-009-0590-z. Epub 2009 Nov 24. Breast Cancer Res Treat. 2010. PMID: 19937272 Free PMC article.
Progressive tumor formation in mice with conditional deletion of TGF-beta signaling in head and neck epithelia is associated with activation of the PI3K/Akt pathway.
Bian Y, Terse A, Du J, Hall B, Molinolo A, Zhang P, Chen W, Flanders KC, Gutkind JS, Wakefield LM, Kulkarni AB. Bian Y, et al. Among authors: flanders kc. Cancer Res. 2009 Jul 15;69(14):5918-26. doi: 10.1158/0008-5472.CAN-08-4623. Epub 2009 Jul 7. Cancer Res. 2009. PMID: 19584284 Free PMC article.
Biological responses to TGF-β in the mammary epithelium show a complex dependency on Smad3 gene dosage with important implications for tumor progression.
Kohn EA, Yang YA, Du Z, Nagano Y, Van Schyndle CM, Herrmann MA, Heldman M, Chen JQ, Stuelten CH, Flanders KC, Wakefield LM. Kohn EA, et al. Among authors: flanders kc. Mol Cancer Res. 2012 Oct;10(10):1389-99. doi: 10.1158/1541-7786.MCR-12-0136-T. Epub 2012 Aug 9. Mol Cancer Res. 2012. PMID: 22878587 Free PMC article.
The Outcome of TGFβ Antagonism in Metastatic Breast Cancer Models In Vivo Reflects a Complex Balance between Tumor-Suppressive and Proprogression Activities of TGFβ.
Yang Y, Yang HH, Tang B, Wu AML, Flanders KC, Moshkovich N, Weinberg DS, Welsh MA, Weng J, Ochoa HJ, Hu TY, Herrmann MA, Chen J, Edmondson EF, Simpson RM, Liu F, Liu H, Lee MP, Wakefield LM. Yang Y, et al. Among authors: flanders kc. Clin Cancer Res. 2020 Feb 1;26(3):643-656. doi: 10.1158/1078-0432.CCR-19-2370. Epub 2019 Oct 3. Clin Cancer Res. 2020. PMID: 31582516 Free PMC article.
179 results