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Cross-linking of protein crystals as an aid in the generation of binary protein-ligand crystal complexes, exemplified by the human PDE10a-papaverine structure.
Andersen OA, Schönfeld DL, Toogood-Johnson I, Felicetti B, Albrecht C, Fryatt T, Whittaker M, Hallett D, Barker J. Andersen OA, et al. Among authors: toogood johnson i. Acta Crystallogr D Biol Crystallogr. 2009 Aug;65(Pt 8):872-4. doi: 10.1107/S0907444909017855. Epub 2009 Jul 17. Acta Crystallogr D Biol Crystallogr. 2009. PMID: 19622871
Discovery and structure-activity relationship of potent and selective covalent inhibitors of transglutaminase 2 for Huntington's disease.
Prime ME, Andersen OA, Barker JJ, Brooks MA, Cheng RK, Toogood-Johnson I, Courtney SM, Brookfield FA, Yarnold CJ, Marston RW, Johnson PD, Johnsen SF, Palfrey JJ, Vaidya D, Erfan S, Ichihara O, Felicetti B, Palan S, Pedret-Dunn A, Schaertl S, Sternberger I, Ebneth A, Scheel A, Winkler D, Toledo-Sherman L, Beconi M, Macdonald D, Muñoz-Sanjuan I, Dominguez C, Wityak J. Prime ME, et al. Among authors: toogood johnson i. J Med Chem. 2012 Feb 9;55(3):1021-46. doi: 10.1021/jm201310y. Epub 2012 Jan 27. J Med Chem. 2012. PMID: 22224594
Peptidomimetic inhibitors of bacterial peptide deformylase.
East SP, Ayscough A, Toogood-Johnson I, Taylor S, Thomas W. East SP, et al. Among authors: toogood johnson i. Bioorg Med Chem Lett. 2011 Jul 1;21(13):4032-5. doi: 10.1016/j.bmcl.2011.04.132. Epub 2011 May 11. Bioorg Med Chem Lett. 2011. PMID: 21621999