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Pharmacological profile of the NOP agonist and cough suppressing agent SCH 486757 (8-[Bis(2-Chlorophenyl)Methyl]-3-(2-Pyrimidinyl)-8-Azabicyclo[3.2.1]Octan-3-Ol) in preclinical models.
McLeod RL, Tulshian DB, Bolser DC, Varty GB, Baptista M, Fernandez X, Parra LE, Zimmer JC, Erickson CH, Ho GD, Jia Y, Ng FW, Korfmacher W, Xu X, Veals J, Smith-Torhan A, Wainhaus S, Fawzi AB, Austin TM, van Heek M, Hey JA. McLeod RL, et al. Among authors: tulshian db. Eur J Pharmacol. 2010 Mar 25;630(1-3):112-20. doi: 10.1016/j.ejphar.2009.12.003. Epub 2009 Dec 16. Eur J Pharmacol. 2010. PMID: 20006596 Free PMC article.
The anxiolytic-like effects of the novel, orally active nociceptin opioid receptor agonist 8-[bis(2-methylphenyl)methyl]-3-phenyl-8-azabicyclo[3.2.1]octan-3-ol (SCH 221510).
Varty GB, Lu SX, Morgan CA, Cohen-Williams ME, Hodgson RA, Smith-Torhan A, Zhang H, Fawzi AB, Graziano MP, Ho GD, Matasi J, Tulshian D, Coffin VL, Carey GJ. Varty GB, et al. J Pharmacol Exp Ther. 2008 Aug;326(2):672-82. doi: 10.1124/jpet.108.136937. Epub 2008 May 20. J Pharmacol Exp Ther. 2008. PMID: 18492950
The discovery of tropane derivatives as nociceptin receptor ligands for the management of cough and anxiety.
Ho GD, Anthes J, Bercovici A, Caldwell JP, Cheng KC, Cui X, Fawzi A, Fernandez X, Greenlee WJ, Hey J, Korfmacher W, Lu SX, McLeod RL, Ng F, Torhan AS, Tan Z, Tulshian D, Varty GB, Xu X, Zhang H. Ho GD, et al. Bioorg Med Chem Lett. 2009 May 1;19(9):2519-23. doi: 10.1016/j.bmcl.2009.03.031. Epub 2009 Mar 14. Bioorg Med Chem Lett. 2009. PMID: 19339177
The anxiolytic-like profile of the nociceptin receptor agonist, endo-8-[bis(2-chlorophenyl)methyl]-3-phenyl-8-azabicyclo[3.2.1]octane-3-carboxamide (SCH 655842): comparison of efficacy and side effects across rodent species.
Lu SX, Higgins GA, Hodgson RA, Hyde LA, Del Vecchio RA, Guthrie DH, Kazdoba T, McCool MF, Morgan CA, Bercovici A, Ho GD, Tulshian D, Parker EM, Hunter JC, Varty GB. Lu SX, et al. Eur J Pharmacol. 2011 Jul 1;661(1-3):63-71. doi: 10.1016/j.ejphar.2011.04.034. Epub 2011 Apr 28. Eur J Pharmacol. 2011. PMID: 21545797
Antitussive profile of the NOP agonist Ro-64-6198 in the guinea pig.
McLeod RL, Jia Y, Fernandez X, Parra LE, Wang X, Tulshian DB, Kiselgof EJ, Tan Z, Fawzi AB, Smith-Torhan A, Zhang H, Hey JA. McLeod RL, et al. Among authors: tulshian db. Pharmacology. 2004 Jul;71(3):143-9. doi: 10.1159/000077448. Pharmacology. 2004. PMID: 15161996
Effect of a novel NOP receptor agonist (SCH 225288) on guinea pig irritant-evoked, feline mechanically induced and canine infectious tracheobronchitis cough.
McLeod RL, Tulshian DB, Ho GD, Fernandez X, Bolser DC, Parra LE, Zimmer JC, Erickson CH, Fawzi AB, Jayappa H, Lehr C, Erskine J, Smith-Torhan A, Zhang H, Hey JA. McLeod RL, et al. Among authors: tulshian db. Pharmacology. 2009;84(3):153-61. doi: 10.1159/000235601. Epub 2009 Aug 20. Pharmacology. 2009. PMID: 19696521
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