Dean DC - Search Results

1

Metabolism and excretion of anacetrapib, a novel inhibitor of the cholesteryl ester transfer protein, in humans.

Kumar S, Tan EY, Hartmann G, Biddle Z, Bergman AJ, Dru J, Ho JZ, Jones AN, Staskiewicz SJ, Braun MP, Karanam B, Dean DC, Gendrano IN, Graves MW, Wagner JA, Krishna R. Kumar S, et al. Among authors: dean dc. Drug Metab Dispos. 2010 Mar;38(3):474-83. doi: 10.1124/dmd.109.028704. Epub 2009 Dec 16. Drug Metab Dispos. 2010. PMID: 20016053 Clinical Trial.

2

Absorption, metabolism, and excretion of [14C]MK-0767 (2-methoxy-5-(2,4-dioxo-5-thiazolidinyl)-N-[[4-(trifluoromethyl)phenyl] methyl]benzamide) in humans.

Kochansky CJ, Rippley RK, Yan KX, Song H, Wallace MA, Dean D, Jones AN, Lasseter K, Schwartz J, Vincent SH, Franklin RB, Wagner J. Kochansky CJ, et al. Drug Metab Dispos. 2006 Sep;34(9):1457-61. doi: 10.1124/dmd.106.010231. Epub 2006 Jun 13. Drug Metab Dispos. 2006. PMID: 16772365 Clinical Trial.

3

Pharmacokinetics, metabolism, and excretion of anacetrapib, a novel inhibitor of the cholesteryl ester transfer protein, in rats and rhesus monkeys.

Tan EY, Hartmann G, Chen Q, Pereira A, Bradley S, Doss G, Zhang AS, Ho JZ, Braun MP, Dean DC, Tang W, Kumar S. Tan EY, et al. Among authors: dean dc. Drug Metab Dispos. 2010 Mar;38(3):459-73. doi: 10.1124/dmd.109.028696. Epub 2009 Dec 16. Drug Metab Dispos. 2010. PMID: 20016052

4

In vitro metabolism of MK-0767 [(+/-)-5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-methoxy-N-[[(4-trifluoromethyl) phenyl]methyl]benzamide], a peroxisome proliferator-activated receptor alpha/gamma agonist. I. Role of cytochrome P450, methyltransferases, flavin monooxygenases, and esterases.

Karanam BV, Hop CE, Liu DQ, Wallace M, Dean D, Satoh H, Komuro M, Awano K, Vincent SH. Karanam BV, et al. Drug Metab Dispos. 2004 Sep;32(9):1015-22. doi: 10.1124/dmd.104.000034. Drug Metab Dispos. 2004. PMID: 15319344

5

Metabolism and excretion of [14C]taranabant, a cannabinoid-1 inverse agonist, in humans.

Karanam B, Addy C, Bateman T, Reddy VB, Li S, Dean D, Li H, Jones A, Schenk D, Zhang AS, Braun M, Freeman A, Flach S, Stoch A, Chodakewitz J, Wagner JA, Kumar S. Karanam B, et al. Xenobiotica. 2010 Oct;40(10):691-700. doi: 10.3109/00498254.2010.509820. Xenobiotica. 2010. PMID: 20722472

6

In vitro metabolic activation of lumiracoxib in rat and human liver preparations.

Li Y, Slatter JG, Zhang Z, Li Y, Doss GA, Braun MP, Stearns RA, Dean DC, Baillie TA, Tang W. Li Y, et al. Among authors: dean dc. Drug Metab Dispos. 2008 Feb;36(2):469-73. doi: 10.1124/dmd.107.019018. Epub 2007 Nov 12. Drug Metab Dispos. 2008. PMID: 17998295

7

Mechanistic studies on the reversible metabolism of rofecoxib to 5-hydroxyrofecoxib in the rat: evidence for transient ring opening of a substituted 2-furanone derivative using stable isotope-labeling techniques.

Baillie TA, Halpin RA, Matuszewski BK, Geer LA, Chavez-Eng CM, Dean D, Braun M, Doss G, Jones A, Marks T, Melillo D, Vyas KP. Baillie TA, et al. Drug Metab Dispos. 2001 Dec;29(12):1614-28. Drug Metab Dispos. 2001. PMID: 11717181

8

The absorption, distribution, metabolism and excretion of rofecoxib, a potent and selective cyclooxygenase-2 inhibitor, in rats and dogs.

Halpin RA, Geer LA, Zhang KE, Marks TM, Dean DC, Jones AN, Melillo D, Doss G, Vyas KP. Halpin RA, et al. Among authors: dean dc. Drug Metab Dispos. 2000 Oct;28(10):1244-54. Drug Metab Dispos. 2000. PMID: 10997947

9

Studies on cytochrome P-450-mediated bioactivation of diclofenac in rats and in human hepatocytes: identification of glutathione conjugated metabolites.

Tang W, Stearns RA, Bandiera SM, Zhang Y, Raab C, Braun MP, Dean DC, Pang J, Leung KH, Doss GA, Strauss JR, Kwei GY, Rushmore TH, Chiu SH, Baillie TA. Tang W, et al. Among authors: dean dc. Drug Metab Dispos. 1999 Mar;27(3):365-72. Drug Metab Dispos. 1999. PMID: 10064567

10

Simultaneous determination of a novel KDR kinase inhibitor and its N-oxide metabolite in human plasma using 96-well solid-phase extraction and liquid chromatography/tandem mass spectrometry.

Xu Y, Du L, Soli ED, Braun MP, Dean DC, Musson DG. Xu Y, et al. Among authors: dean dc. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Mar 25;817(2):287-96. doi: 10.1016/j.jchromb.2004.12.019. J Chromatogr B Analyt Technol Biomed Life Sci. 2005. PMID: 15686997

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