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Institutional profile. UNC Institute for Pharmacogenomics and Individualized Therapy: interdisciplinary research for individual care.
Rakhra-Burris TK, Auman JT, Deverka P, Dressler LG, Evans JP, Goldberg RM, Havener TM, Hoskins JM, Jonas DE, Long KM, Motsinger-Reif AA, Irvin WJ, Richards KL, Roederer MW, Valgus JM, Riper Mv, Vernon JA, Zamboni WC, Wagner MJ, Walko CM, Weck KE, Wiltshire T, McLeod HL. Rakhra-Burris TK, et al. Among authors: irvin wj. Pharmacogenomics. 2010 Jan;11(1):13-21. doi: 10.2217/pgs.09.167. Pharmacogenomics. 2010. PMID: 20017668 Free article.
Genotype-guided tamoxifen dosing increases active metabolite exposure in women with reduced CYP2D6 metabolism: a multicenter study.
Irvin WJ Jr, Walko CM, Weck KE, Ibrahim JG, Chiu WK, Dees EC, Moore SG, Olajide OA, Graham ML, Canale ST, Raab RE, Corso SW, Peppercorn JM, Anderson SM, Friedman KJ, Ogburn ET, Desta Z, Flockhart DA, McLeod HL, Evans JP, Carey LA. Irvin WJ Jr, et al. J Clin Oncol. 2011 Aug 20;29(24):3232-9. doi: 10.1200/JCO.2010.31.4427. Epub 2011 Jul 18. J Clin Oncol. 2011. PMID: 21768473 Free PMC article.
Tamoxifen and CYP2D6: a contradiction of data.
Hertz DL, McLeod HL, Irvin WJ Jr. Hertz DL, et al. Among authors: irvin wj jr. Oncologist. 2012;17(5):620-30. doi: 10.1634/theoncologist.2011-0418. Epub 2012 Apr 24. Oncologist. 2012. PMID: 22531359 Free PMC article. Review.
Patients' understanding of how genotype variation affects benefits of tamoxifen therapy for breast cancer.
Brewer NT, Defrank JT, Chiu WK, Ibrahim JG, Walko CM, Rubin P, Olajide OA, Moore SG, Raab RE, Carrizosa DR, Corso SW, Schwartz G, Peppercorn JM, McLeod HL, Carey LA, Irvin WJ Jr. Brewer NT, et al. Among authors: irvin wj jr. Public Health Genomics. 2014;17(1):43-7. doi: 10.1159/000356565. Epub 2014 Jan 22. Public Health Genomics. 2014. PMID: 24457521 Free PMC article.
In vivo assessment of the metabolic activity of CYP2D6 diplotypes and alleles.
Hertz DL, Snavely AC, McLeod HL, Walko CM, Ibrahim JG, Anderson S, Weck KE, Magrinat G, Olajide O, Moore S, Raab R, Carrizosa DR, Corso S, Schwartz G, Peppercorn JM, Evans JP, Jones DR, Desta Z, Flockhart DA, Carey LA, Irvin WJ Jr. Hertz DL, et al. Among authors: irvin wj jr. Br J Clin Pharmacol. 2015 Nov;80(5):1122-30. doi: 10.1111/bcp.12665. Epub 2015 Aug 2. Br J Clin Pharmacol. 2015. PMID: 25907378 Free PMC article. Clinical Trial.
Tamoxifen Dose Escalation in Patients With Diminished CYP2D6 Activity Normalizes Endoxifen Concentrations Without Increasing Toxicity.
Hertz DL, Deal A, Ibrahim JG, Walko CM, Weck KE, Anderson S, Magrinat G, Olajide O, Moore S, Raab R, Carrizosa DR, Corso S, Schwartz G, Graham M, Peppercorn JM, Jones DR, Desta Z, Flockhart DA, Evans JP, McLeod HL, Carey LA, Irvin WJ Jr. Hertz DL, et al. Among authors: irvin wj jr. Oncologist. 2016 Jul;21(7):795-803. doi: 10.1634/theoncologist.2015-0480. Epub 2016 May 25. Oncologist. 2016. PMID: 27226358 Free PMC article.
Comprehensive assessment of cytochromes P450 and transporter genetics with endoxifen concentration during tamoxifen treatment.
Marcath LA, Deal AM, Van Wieren E, Danko W, Walko CM, Ibrahim JG, Weck KE, Jones DR, Desta Z, McLeod HL, Carey LA, Irvin WJ Jr, Hertz DL. Marcath LA, et al. Among authors: irvin wj jr. Pharmacogenet Genomics. 2017 Nov;27(11):402-409. doi: 10.1097/FPC.0000000000000311. Pharmacogenet Genomics. 2017. PMID: 28877533 Free PMC article.
What is triple-negative breast cancer?
Irvin WJ Jr, Carey LA. Irvin WJ Jr, et al. Eur J Cancer. 2008 Dec;44(18):2799-805. doi: 10.1016/j.ejca.2008.09.034. Epub 2008 Nov 12. Eur J Cancer. 2008. PMID: 19008097 Review.
31 results