Kowalski TJ - Search Results

1

Diaryl piperidines as CB1 receptor antagonists.

Scott JD, Li SW, Wang H, Xia Y, Jayne CL, Miller MW, Duffy RA, Boykow GC, Kowalski TJ, Spar BD, Stamford AW, Chackalamannil S, Lachowicz JE, Greenlee WJ. Scott JD, et al. Among authors: kowalski tj. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1278-83. doi: 10.1016/j.bmcl.2009.11.075. Epub 2009 Nov 20. Bioorg Med Chem Lett. 2010. PMID: 20018510

2

Discovery of a nortropanol derivative as a potent and orally active GPR119 agonist for type 2 diabetes.

Xia Y, Chackalamannil S, Greenlee WJ, Jayne C, Neustadt B, Stamford A, Vaccaro H, Xu XL, Baker H, O'Neill K, Woods M, Hawes B, Kowalski T. Xia Y, et al. Bioorg Med Chem Lett. 2011 Jun 1;21(11):3290-6. doi: 10.1016/j.bmcl.2011.04.035. Epub 2011 Apr 14. Bioorg Med Chem Lett. 2011. PMID: 21536438

3

Design and synthesis of orally efficacious benzimidazoles as melanin-concentrating hormone receptor 1 antagonists.

Wu WL, Burnett DA, Caplen MA, Domalski MS, Bennett C, Greenlee WJ, Hawes BE, O'Neill K, Weig B, Weston D, Spar B, Kowalski T. Wu WL, et al. Bioorg Med Chem Lett. 2006 Jul 15;16(14):3674-8. doi: 10.1016/j.bmcl.2006.04.062. Epub 2006 May 11. Bioorg Med Chem Lett. 2006. PMID: 16690315

4

SAR study of bicyclo[4.1.0]heptanes as melanin-concentrating hormone receptor R1 antagonists: taming hERG.

Su J, McKittrick BA, Tang H, Burnett DA, Clader JW, Greenlee WJ, Hawes BE, O'Neill K, Spar B, Weig B, Kowalski T, Sorota S, Li C, Liu T. Su J, et al. Bioorg Med Chem. 2007 Aug 15;15(16):5369-85. doi: 10.1016/j.bmc.2007.05.068. Epub 2007 Jun 2. Bioorg Med Chem. 2007. PMID: 17572094

5

Synthesis of novel bicyclo[4.1.0]heptane and bicyclo[3.1.0]hexane derivatives as melanin-concentrating hormone receptor R1 antagonists.

Su J, Tang H, McKittrick BA, Gu H, Guo T, Qian G, Burnett DA, Clader JW, Greenlee WJ, Hawes BE, O'neill K, Spar B, Weig B, Kowalski T, Sorota S. Su J, et al. Bioorg Med Chem Lett. 2007 Sep 1;17(17):4845-50. doi: 10.1016/j.bmcl.2007.06.048. Epub 2007 Jun 17. Bioorg Med Chem Lett. 2007. PMID: 17604169

6

Discovery of bicycloalkyl urea melanin concentrating hormone receptor antagonists: orally efficacious antiobesity therapeutics.

McBriar MD, Guzik H, Xu R, Paruchova J, Li S, Palani A, Clader JW, Greenlee WJ, Hawes BE, Kowalski TJ, O'Neill K, Spar B, Weig B. McBriar MD, et al. Among authors: kowalski tj. J Med Chem. 2005 Apr 7;48(7):2274-7. doi: 10.1021/jm049035q. J Med Chem. 2005. PMID: 15801820

7

Biaryl ureas as potent and orally efficacious melanin concentrating hormone receptor 1 antagonists for the treatment of obesity.

Palani A, Shapiro S, McBriar MD, Clader JW, Greenlee WJ, Spar B, Kowalski TJ, Farley C, Cook J, van Heek M, Weig B, O'neill K, Graziano M, Hawes B. Palani A, et al. Among authors: kowalski tj. J Med Chem. 2005 Jul 28;48(15):4746-9. doi: 10.1021/jm0503852. J Med Chem. 2005. PMID: 16033253

8

Bicyclic[4.1.0]heptanes as phenyl replacements for melanin concentrating hormone receptor antagonists.

Xu R, Li S, Paruchova J, McBriar MD, Guzik H, Palani A, Clader JW, Cox K, Greenlee WJ, Hawes BE, Kowalski TJ, O'Neill K, Spar BD, Weig B, Weston DJ. Xu R, et al. Among authors: kowalski tj. Bioorg Med Chem. 2006 May 15;14(10):3285-99. doi: 10.1016/j.bmc.2005.12.046. Epub 2006 Jan 26. Bioorg Med Chem. 2006. PMID: 16442800

9

Discovery of orally efficacious melanin-concentrating hormone receptor-1 antagonists as antiobesity agents. Synthesis, SAR, and biological evaluation of bicyclo[3.1.0]hexyl ureas.

McBriar MD, Guzik H, Shapiro S, Paruchova J, Xu R, Palani A, Clader JW, Cox K, Greenlee WJ, Hawes BE, Kowalski TJ, O'neill K, Spar BD, Weig B, Weston DJ, Farley C, Cook J. McBriar MD, et al. Among authors: kowalski tj. J Med Chem. 2006 Apr 6;49(7):2294-310. doi: 10.1021/jm050886n. J Med Chem. 2006. PMID: 16570926

10

Novel aminobenzimidazoles as selective MCH-R1 antagonists for the treatment of metabolic diseases.

Sasikumar TK, Qiang L, Burnett DA, Greenlee WJ, Hawes BE, Kowalski TJ, O'Neill K, Spar BD, Weig B. Sasikumar TK, et al. Among authors: kowalski tj. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5427-31. doi: 10.1016/j.bmcl.2006.07.058. Epub 2006 Aug 2. Bioorg Med Chem Lett. 2006. PMID: 16889961

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