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Mutations in the perforin gene can be linked to macrophage activation syndrome in patients with systemic onset juvenile idiopathic arthritis.
Vastert SJ, van Wijk R, D'Urbano LE, de Vooght KM, de Jager W, Ravelli A, Magni-Manzoni S, Insalaco A, Cortis E, van Solinge WW, Prakken BJ, Wulffraat NM, de Benedetti F, Kuis W. Vastert SJ, et al. Among authors: de vooght km, de benedetti f, de jager w. Rheumatology (Oxford). 2010 Mar;49(3):441-9. doi: 10.1093/rheumatology/kep418. Epub 2009 Dec 17. Rheumatology (Oxford). 2010. PMID: 20019066
The spontaneous remission of juvenile idiopathic arthritis is characterized by CD30+ T cells directed to human heat-shock protein 60 capable of producing the regulatory cytokine interleukin-10.
de Kleer IM, Kamphuis SM, Rijkers GT, Scholtens L, Gordon G, De Jager W, Häfner R, van de Zee R, van Eden W, Kuis W, Prakken BJ. de Kleer IM, et al. Among authors: de jager w. Arthritis Rheum. 2003 Jul;48(7):2001-10. doi: 10.1002/art.11174. Arthritis Rheum. 2003. PMID: 12847694 Free article.
Novel self-epitopes derived from aggrecan, fibrillin, and matrix metalloproteinase-3 drive distinct autoreactive T-cell responses in juvenile idiopathic arthritis and in health.
Kamphuis S, Hrafnkelsdóttir K, Klein MR, de Jager W, Haverkamp MH, van Bilsen JH, Albani S, Kuis W, Wauben MH, Prakken BJ. Kamphuis S, et al. Among authors: de jager w. Arthritis Res Ther. 2006;8(6):R178. doi: 10.1186/ar2088. Arthritis Res Ther. 2006. PMID: 17129378 Free PMC article.
127 results