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Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors.
Zhang J, Adrián FJ, Jahnke W, Cowan-Jacob SW, Li AG, Iacob RE, Sim T, Powers J, Dierks C, Sun F, Guo GR, Ding Q, Okram B, Choi Y, Wojciechowski A, Deng X, Liu G, Fendrich G, Strauss A, Vajpai N, Grzesiek S, Tuntland T, Liu Y, Bursulaya B, Azam M, Manley PW, Engen JR, Daley GQ, Warmuth M, Gray NS. Zhang J, et al. Among authors: engen jr. Nature. 2010 Jan 28;463(7280):501-6. doi: 10.1038/nature08675. Epub 2010 Jan 13. Nature. 2010. PMID: 20072125 Free PMC article.
Conformational disturbance in Abl kinase upon mutation and deregulation.
Iacob RE, Pene-Dumitrescu T, Zhang J, Gray NS, Smithgall TE, Engen JR. Iacob RE, et al. Among authors: engen jr. Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1386-91. doi: 10.1073/pnas.0811912106. Epub 2009 Jan 21. Proc Natl Acad Sci U S A. 2009. PMID: 19164531 Free PMC article.
Novel mutant-selective EGFR kinase inhibitors against EGFR T790M.
Zhou W, Ercan D, Chen L, Yun CH, Li D, Capelletti M, Cortot AB, Chirieac L, Iacob RE, Padera R, Engen JR, Wong KK, Eck MJ, Gray NS, Jänne PA. Zhou W, et al. Among authors: engen jr. Nature. 2009 Dec 24;462(7276):1070-4. doi: 10.1038/nature08622. Nature. 2009. PMID: 20033049 Free PMC article.
Hydrogen exchange mass spectrometry: are we out of the quicksand?
Iacob RE, Engen JR. Iacob RE, et al. Among authors: engen jr. J Am Soc Mass Spectrom. 2012 Jun;23(6):1003-10. doi: 10.1007/s13361-012-0377-z. Epub 2012 Apr 3. J Am Soc Mass Spectrom. 2012. PMID: 22476891 Free PMC article. Review.
Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors.
Yu W, Chory EJ, Wernimont AK, Tempel W, Scopton A, Federation A, Marineau JJ, Qi J, Barsyte-Lovejoy D, Yi J, Marcellus R, Iacob RE, Engen JR, Griffin C, Aman A, Wienholds E, Li F, Pineda J, Estiu G, Shatseva T, Hajian T, Al-Awar R, Dick JE, Vedadi M, Brown PJ, Arrowsmith CH, Bradner JE, Schapira M. Yu W, et al. Among authors: engen jr. Nat Commun. 2012;3:1288. doi: 10.1038/ncomms2304. Nat Commun. 2012. PMID: 23250418 Free article.
191 results