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The mitochondrial ribosomal protein of the large subunit, Afo1p, determines cellular longevity through mitochondrial back-signaling via TOR1.
Heeren G, Rinnerthaler M, Laun P, von Seyerl P, Kössler S, Klinger H, Hager M, Bogengruber E, Jarolim S, Simon-Nobbe B, Schüller C, Carmona-Gutierrez D, Breitenbach-Koller L, Mück C, Jansen-Dürr P, Criollo A, Kroemer G, Madeo F, Breitenbach M. Heeren G, et al. Aging (Albany NY). 2009 Jul 13;1(7):622-36. doi: 10.18632/aging.100065. Aging (Albany NY). 2009. PMID: 20157544 Free PMC article.
Identification of evolutionarily conserved genetic regulators of cellular aging.
Laschober GT, Ruli D, Hofer E, Muck C, Carmona-Gutierrez D, Ring J, Hutter E, Ruckenstuhl C, Micutkova L, Brunauer R, Jamnig A, Trimmel D, Herndler-Brandstetter D, Brunner S, Zenzmaier C, Sampson N, Breitenbach M, Fröhlich KU, Grubeck-Loebenstein B, Berger P, Wieser M, Grillari-Voglauer R, Thallinger GG, Grillari J, Trajanoski Z, Madeo F, Lepperdinger G, Jansen-Dürr P. Laschober GT, et al. Aging Cell. 2010 Dec;9(6):1084-97. doi: 10.1111/j.1474-9726.2010.00637.x. Epub 2010 Oct 28. Aging Cell. 2010. PMID: 20883526 Free PMC article.
miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging.
Hackl M, Brunner S, Fortschegger K, Schreiner C, Micutkova L, Mück C, Laschober GT, Lepperdinger G, Sampson N, Berger P, Herndler-Brandstetter D, Wieser M, Kühnel H, Strasser A, Rinnerthaler M, Breitenbach M, Mildner M, Eckhart L, Tschachler E, Trost A, Bauer JW, Papak C, Trajanoski Z, Scheideler M, Grillari-Voglauer R, Grubeck-Loebenstein B, Jansen-Dürr P, Grillari J. Hackl M, et al. Aging Cell. 2010 Apr;9(2):291-6. doi: 10.1111/j.1474-9726.2010.00549.x. Epub 2010 Jan 18. Aging Cell. 2010. PMID: 20089119 Free PMC article.
Lifespan extension by methionine restriction requires autophagy-dependent vacuolar acidification.
Ruckenstuhl C, Netzberger C, Entfellner I, Carmona-Gutierrez D, Kickenweiz T, Stekovic S, Gleixner C, Schmid C, Klug L, Sorgo AG, Eisenberg T, Büttner S, Mariño G, Koziel R, Jansen-Dürr P, Fröhlich KU, Kroemer G, Madeo F. Ruckenstuhl C, et al. PLoS Genet. 2014 May 1;10(5):e1004347. doi: 10.1371/journal.pgen.1004347. eCollection 2014 May. PLoS Genet. 2014. PMID: 24785424 Free PMC article.
165 results