Schemies J - Search Results

1

Malyngolide dimer, a bioactive symmetric cyclodepside from the panamanian marine cyanobacterium Lyngbya majuscula.

Gutiérrez M, Tidgewell K, Capson TL, Engene N, Almanza A, Schemies J, Jung M, Gerwick WH. Gutiérrez M, et al. Among authors: schemies j. J Nat Prod. 2010 Apr 23;73(4):709-11. doi: 10.1021/np9005184. J Nat Prod. 2010. PMID: 20158242 Free PMC article.

2

Structural and synthetic investigations of tanikolide dimer, a SIRT2 selective inhibitor, and tanikolide seco-acid from the Madagascar marine cyanobacterium Lyngbya majuscula.

Gutiérrez M, Andrianasolo EH, Shin WK, Goeger DE, Yokochi A, Schemies J, Jung M, France D, Cornell-Kennon S, Lee E, Gerwick WH. Gutiérrez M, et al. Among authors: schemies j. J Org Chem. 2009 Aug 7;74(15):5267-75. doi: 10.1021/jo900578j. J Org Chem. 2009. PMID: 19572575 Free PMC article.

3

Histone deacetylase inhibitors that target tubulin.

Schemies J, Sippl W, Jung M. Schemies J, et al. Cancer Lett. 2009 Aug 8;280(2):222-32. doi: 10.1016/j.canlet.2009.01.040. Epub 2009 Mar 5. Cancer Lett. 2009. PMID: 19268440 Review.

4

NAD(+) -dependent histone deacetylases (sirtuins) as novel therapeutic targets.

Schemies J, Uciechowska U, Sippl W, Jung M. Schemies J, et al. Med Res Rev. 2010 Nov;30(6):861-89. doi: 10.1002/med.20178. Med Res Rev. 2010. PMID: 19824050 Review.

5

Thiobarbiturates as sirtuin inhibitors: virtual screening, free-energy calculations, and biological testing.

Uciechowska U, Schemies J, Neugebauer RC, Huda EM, Schmitt ML, Meier R, Verdin E, Jung M, Sippl W. Uciechowska U, et al. Among authors: schemies j. ChemMedChem. 2008 Dec;3(12):1965-76. doi: 10.1002/cmdc.200800104. ChemMedChem. 2008. PMID: 18985648

6

Two-step synthesis of novel, bioactive derivatives of the ubiquitous cofactor nicotinamide adenine dinucleotide (NAD).

Pesnot T, Kempter J, Schemies J, Pergolizzi G, Uciechowska U, Rumpf T, Sippl W, Jung M, Wagner GK. Pesnot T, et al. Among authors: schemies j. J Med Chem. 2011 May 26;54(10):3492-9. doi: 10.1021/jm1013852. Epub 2011 Apr 29. J Med Chem. 2011. PMID: 21528845

7

Inhibitors to understand molecular mechanisms of NAD(+)-dependent deacetylases (sirtuins).

Lawson M, Uciechowska U, Schemies J, Rumpf T, Jung M, Sippl W. Lawson M, et al. Among authors: schemies j. Biochim Biophys Acta. 2010 Oct-Dec;1799(10-12):726-39. doi: 10.1016/j.bbagrm.2010.06.003. Epub 2010 Jun 23. Biochim Biophys Acta. 2010. PMID: 20601279 Review.

8

Synthesis and biological activity of splitomicin analogs targeted at human NAD(+)-dependent histone deacetylases (sirtuins).

Freitag M, Schemies J, Larsen T, El Gaghlab K, Schulz F, Rumpf T, Jung M, Link A. Freitag M, et al. Among authors: schemies j. Bioorg Med Chem. 2011 Jun 15;19(12):3669-77. doi: 10.1016/j.bmc.2011.01.026. Epub 2011 Jan 22. Bioorg Med Chem. 2011. PMID: 21315612

9

Novel 3-arylideneindolin-2-ones as inhibitors of NAD+ -dependent histone deacetylases (sirtuins).

Huber K, Schemies J, Uciechowska U, Wagner JM, Rumpf T, Lewrick F, Süss R, Sippl W, Jung M, Bracher F. Huber K, et al. Among authors: schemies j. J Med Chem. 2010 Feb 11;53(3):1383-6. doi: 10.1021/jm901055u. J Med Chem. 2010. PMID: 20030343

10

Benzodeazaoxaflavins as sirtuin inhibitors with antiproliferative properties in cancer stem cells.

Rotili D, Tarantino D, Carafa V, Paolini C, Schemies J, Jung M, Botta G, Di Maro S, Novellino E, Steinkühler C, De Maria R, Gallinari P, Altucci L, Mai A. Rotili D, et al. Among authors: schemies j. J Med Chem. 2012 Sep 27;55(18):8193-7. doi: 10.1021/jm301115r. Epub 2012 Sep 7. J Med Chem. 2012. PMID: 22931526

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