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Page 1
Discovery of substituted biphenyl imidazoles as potent, bioavailable bombesin receptor subtype-3 agonists.
He S, Dobbelaar PH, Liu J, Jian T, Sebhat IK, Lin LS, Goodman A, Guo C, Guzzo PR, Hadden M, Henderson AJ, Ruenz M, Sargent BJ, Yet L, Kelly TM, Palyha O, Kan Y, Pan J, Chen H, Marsh DJ, Shearman LP, Strack AM, Metzger JM, Feighner SD, Tan C, Howard AD, Tamvakopoulos C, Peng Q, Guan XM, Reitman ML, Patchett AA, Wyvratt MJ Jr, Nargund RP. He S, et al. Among authors: hadden m. Bioorg Med Chem Lett. 2010 Mar 15;20(6):1913-7. doi: 10.1016/j.bmcl.2010.01.154. Epub 2010 Feb 4. Bioorg Med Chem Lett. 2010. PMID: 20167483
Synthesis and SAR of derivatives based on 2-biarylethylimidazole as bombesin receptor subtype-3 (BRS-3) agonists for the treatment of obesity.
Liu J, He S, Jian T, Dobbelaar PH, Sebhat IK, Lin LS, Goodman A, Guo C, Guzzo PR, Hadden M, Henderson AJ, Pattamana K, Ruenz M, Sargent BJ, Swenson B, Yet L, Tamvakopoulos C, Peng Q, Pan J, Kan Y, Palyha O, Kelly TM, Guan XM, Howard AD, Marsh DJ, Metzger JM, Reitman ML, Wyvratt MJ, Nargund RP. Liu J, et al. Among authors: hadden m. Bioorg Med Chem Lett. 2010 Apr 1;20(7):2074-7. doi: 10.1016/j.bmcl.2010.02.076. Epub 2010 Feb 21. Bioorg Med Chem Lett. 2010. PMID: 20219372
Synthesis and SAR of heterocyclic carboxylic acid isosteres based on 2-biarylethylimidazole as bombesin receptor subtype-3 (BRS-3) agonists for the treatment of obesity.
Hadden M, Goodman A, Guo C, Guzzo PR, Henderson AJ, Pattamana K, Ruenz M, Sargent BJ, Swenson B, Yet L, Liu J, He S, Sebhat IK, Lin LS, Tamvakopoulos C, Peng Q, Kan Y, Palyha O, Kelly TM, Guan XM, Metzger JM, Reitman ML, Nargund RP. Hadden M, et al. Bioorg Med Chem Lett. 2010 May 1;20(9):2912-5. doi: 10.1016/j.bmcl.2010.03.028. Epub 2010 Mar 12. Bioorg Med Chem Lett. 2010. PMID: 20347296
Synthesis of 7-benzyl-5-(piperidin-1-yl)-6,7,8,9-tetrahydro-3H-pyrazolo[3,4-c][2,7]naphthyridin-1-ylamine and its analogs as bombesin receptor subtype-3 agonists.
Guo C, Guzzo PR, Hadden M, Sargent BJ, Yet L, Kan Y, Palyha O, Kelly TM, Guan X, Rosko K, Gagen K, Metzger JM, Dragovic J, Lyons K, Lin LS, Nargund RP. Guo C, et al. Among authors: hadden m. Bioorg Med Chem Lett. 2010 May 1;20(9):2785-9. doi: 10.1016/j.bmcl.2010.03.065. Epub 2010 Mar 17. Bioorg Med Chem Lett. 2010. PMID: 20371178
Tetrahydrocarboline analogs as MCH-1 antagonists.
Henderson AJ, Deering D, Grabowski JF, Hadden M, Jiang X, Khmelnitsky Y, Luche M, Surman MD, Cheetham S, Vickers S, Viggers J, Guzzo PR. Henderson AJ, et al. Among authors: hadden m. Bioorg Med Chem Lett. 2010 Dec 1;20(23):7024-8. doi: 10.1016/j.bmcl.2010.09.122. Epub 2010 Sep 29. Bioorg Med Chem Lett. 2010. PMID: 20952195
5-(pyridinon-1-yl)indazoles and 5-(furopyridinon-5-yl)indazoles as MCH-1 antagonists.
Surman MD, Freeman EE, Grabowski JF, Hadden M, Henderson AJ, Jiang G, Jiang XM, Luche M, Khmelnitsky Y, Vickers S, Viggers J, Cheetham S, Guzzo PR. Surman MD, et al. Among authors: hadden m. Bioorg Med Chem Lett. 2010 Dec 1;20(23):7015-9. doi: 10.1016/j.bmcl.2010.09.039. Epub 2010 Sep 16. Bioorg Med Chem Lett. 2010. PMID: 20961756
2,3-Diaminopyrazines as Rho kinase inhibitors.
Henderson AJ, Hadden M, Guo C, Douglas N, Decornez H, Hellberg MR, Rusinko A, McLaughlin M, Sharif N, Drace C, Patil R. Henderson AJ, et al. Among authors: hadden m. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1137-40. doi: 10.1016/j.bmcl.2009.12.012. Epub 2009 Dec 5. Bioorg Med Chem Lett. 2010. PMID: 20022494
Structure-activity relationships of anthranilamide-based factor Xa inhibitors containing piperidinone and pyridinone P4 moieties.
Corte JR, Fang T, Pinto DJ, Han W, Hu Z, Jiang XJ, Li YL, Gauuan JF, Hadden M, Orton D, Rendina AR, Luettgen JM, Wong PC, He K, Morin PE, Chang CH, Cheney DL, Knabb RM, Wexler RR, Lam PY. Corte JR, et al. Among authors: hadden m. Bioorg Med Chem Lett. 2008 May 1;18(9):2845-9. doi: 10.1016/j.bmcl.2008.03.092. Epub 2008 Apr 8. Bioorg Med Chem Lett. 2008. PMID: 18424044
94 results