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A phase 1b clinical trial evaluating sifalimumab, an anti-IFN-α monoclonal antibody, shows target neutralisation of a type I IFN signature in blood of dermatomyositis and polymyositis patients.
Higgs BW, Zhu W, Morehouse C, White WI, Brohawn P, Guo X, Rebelatto M, Le C, Amato A, Fiorentino D, Greenberg SA, Drappa J, Richman L, Greth W, Jallal B, Yao Y. Higgs BW, et al. Ann Rheum Dis. 2014 Jan;73(1):256-62. doi: 10.1136/annrheumdis-2012-202794. Epub 2013 Feb 23. Ann Rheum Dis. 2014. PMID: 23434567 Free PMC article. Clinical Trial.
Type I interferon: potential therapeutic target for psoriasis?
Yao Y, Richman L, Morehouse C, de los Reyes M, Higgs BW, Boutrin A, White B, Coyle A, Krueger J, Kiener PA, Jallal B. Yao Y, et al. Among authors: higgs bw. PLoS One. 2008 Jul 16;3(7):e2737. doi: 10.1371/journal.pone.0002737. PLoS One. 2008. PMID: 18648529 Free PMC article.
Genomic signatures characterize leukocyte infiltration in myositis muscles.
Zhu W, Streicher K, Shen N, Higgs BW, Morehouse C, Greenlees L, Amato AA, Ranade K, Richman L, Fiorentino D, Jallal B, Greenberg SA, Yao Y. Zhu W, et al. Among authors: higgs bw. BMC Med Genomics. 2012 Nov 21;5:53. doi: 10.1186/1755-8794-5-53. BMC Med Genomics. 2012. PMID: 23171592 Free PMC article.
Inhibition of myogenic microRNAs 1, 133, and 206 by inflammatory cytokines links inflammation and muscle degeneration in adult inflammatory myopathies.
Georgantas RW, Streicher K, Greenberg SA, Greenlees LM, Zhu W, Brohawn PZ, Higgs BW, Czapiga M, Morehouse CA, Amato A, Richman L, Jallal B, Yao Y, Ranade K. Georgantas RW, et al. Among authors: higgs bw. Arthritis Rheumatol. 2014 Apr;66(4):1022-33. doi: 10.1002/art.38292. Arthritis Rheumatol. 2014. PMID: 24757153
100 results