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Stereochemistry-activity relationship of orally active tetralin S1P agonist prodrugs.
Bioorg Med Chem Lett. 2010 Apr 1;20(7):2264-9. doi: 10.1016/j.bmcl.2010.02.006. Epub 2010 Feb 6.
Bioorg Med Chem Lett. 2010.
PMID: 20188554
Free PMC article.
Discovery of 4-aminomethylphenylacetic acids as γ-secretase modulators via a scaffold design approach.
Xin Z, Peng H, Zhang A, Talreja T, Kumaravel G, Xu L, Rohde E, Jung MY, Shackett MN, Kocisko D, Chollate S, Dunah AW, Snodgrass-Belt PA, Arnold HM, Taveras AG, Rhodes KJ, Scannevin RH.
Xin Z, et al. Among authors: chollate s.
Bioorg Med Chem Lett. 2011 Dec 15;21(24):7277-80. doi: 10.1016/j.bmcl.2011.10.047. Epub 2011 Oct 19.
Bioorg Med Chem Lett. 2011.
PMID: 22061640
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Discovery of BIIB042, a Potent, Selective, and Orally Bioavailable γ-Secretase Modulator.
Peng H, Talreja T, Xin Z, Cuervo JH, Kumaravel G, Humora MJ, Xu L, Rohde E, Gan L, Jung MY, Shackett MN, Chollate S, Dunah AW, Snodgrass-Belt PA, Arnold HM, Taveras AG, Rhodes KJ, Scannevin RH.
Peng H, et al. Among authors: chollate s.
ACS Med Chem Lett. 2011 Aug 5;2(10):786-91. doi: 10.1021/ml200175q. eCollection 2011 Oct 13.
ACS Med Chem Lett. 2011.
PMID: 24900267
Free PMC article.
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BIIB042, a novel γ-secretase modulator, reduces amyloidogenic Aβ isoforms in primates and rodents and plaque pathology in a mouse model of Alzheimer's disease.
Scannevin RH, Chollate S, Brennan MS, Snodgrass-Belt PA, Peng H, Xu L, Jung MY, Bussiere T, Arastu MF, Talreja T, Xin Z, Dunstan RW, Fahrer D, Rohde E, Dunah AW, Wang J, Kumaravel G, Taveras AG, Moore Arnold H, Rhodes KJ.
Scannevin RH, et al. Among authors: chollate s.
Neuropharmacology. 2016 Apr;103:57-68. doi: 10.1016/j.neuropharm.2015.12.006. Epub 2015 Dec 12.
Neuropharmacology. 2016.
PMID: 26690893
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Fumarates promote cytoprotection of central nervous system cells against oxidative stress via the nuclear factor (erythroid-derived 2)-like 2 pathway.
Scannevin RH, Chollate S, Jung MY, Shackett M, Patel H, Bista P, Zeng W, Ryan S, Yamamoto M, Lukashev M, Rhodes KJ.
Scannevin RH, et al. Among authors: chollate s.
J Pharmacol Exp Ther. 2012 Apr;341(1):274-84. doi: 10.1124/jpet.111.190132. Epub 2012 Jan 20.
J Pharmacol Exp Ther. 2012.
PMID: 22267202
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The antibody aducanumab reduces Aβ plaques in Alzheimer's disease.
Sevigny J, Chiao P, Bussière T, Weinreb PH, Williams L, Maier M, Dunstan R, Salloway S, Chen T, Ling Y, O'Gorman J, Qian F, Arastu M, Li M, Chollate S, Brennan MS, Quintero-Monzon O, Scannevin RH, Arnold HM, Engber T, Rhodes K, Ferrero J, Hang Y, Mikulskis A, Grimm J, Hock C, Nitsch RM, Sandrock A.
Sevigny J, et al. Among authors: chollate s.
Nature. 2016 Sep 1;537(7618):50-6. doi: 10.1038/nature19323.
Nature. 2016.
PMID: 27582220
Updated.
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Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway.
Linker RA, Lee DH, Ryan S, van Dam AM, Conrad R, Bista P, Zeng W, Hronowsky X, Buko A, Chollate S, Ellrichmann G, Brück W, Dawson K, Goelz S, Wiese S, Scannevin RH, Lukashev M, Gold R.
Linker RA, et al. Among authors: chollate s.
Brain. 2011 Mar;134(Pt 3):678-92. doi: 10.1093/brain/awq386.
Brain. 2011.
PMID: 21354971
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Addendum: The antibody aducanumab reduces Aβ plaques in Alzheimer's disease.
Sevigny J, Chiao P, Bussière T, Weinreb PH, Williams L, Maier M, Dunstan R, Salloway S, Chen T, Ling Y, O'Gorman J, Qian F, Arastu M, Li M, Chollate S, Brennan MS, Quintero-Monzon O, Scannevin RH, Arnold HM, Engber T, Rhodes K, Ferrero J, Hang Y, Mikulskis A, Grimm J, Hock C, Nitsch RM, Sandrock A.
Sevigny J, et al. Among authors: chollate s.
Nature. 2017 Jun 21;546(7659):564. doi: 10.1038/nature22809.
Nature. 2017.
PMID: 28640269
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