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Page 1
Stereochemistry-activity relationship of orally active tetralin S1P agonist prodrugs.
Ma B, Guckian KM, Lin EY, Lee WC, Scott D, Kumaravel G, Macdonald TL, Lynch KR, Black C, Chollate S, Hahm K, Hetu G, Jin P, Luo Y, Rohde E, Rossomando A, Scannevin R, Wang J, Yang C. Ma B, et al. Among authors: guckian km. Bioorg Med Chem Lett. 2010 Apr 1;20(7):2264-9. doi: 10.1016/j.bmcl.2010.02.006. Epub 2010 Feb 6. Bioorg Med Chem Lett. 2010. PMID: 20188554 Free PMC article.
Pyrazolone based TGFbetaR1 kinase inhibitors.
Guckian K, Carter MB, Lin EY, Choi M, Sun L, Boriack-Sjodin PA, Chuaqui C, Lane B, Cheung K, Ling L, Lee WC. Guckian K, et al. Bioorg Med Chem Lett. 2010 Jan 1;20(1):326-9. doi: 10.1016/j.bmcl.2009.10.108. Epub 2009 Oct 29. Bioorg Med Chem Lett. 2010. PMID: 19914068
Potent PDZ-Domain PICK1 Inhibitors that Modulate Amyloid Beta-Mediated Synaptic Dysfunction.
Lin EYS, Silvian LF, Marcotte DJ, Banos CC, Jow F, Chan TR, Arduini RM, Qian F, Baker DP, Bergeron C, Hession CA, Huganir RL, Borenstein CF, Enyedy I, Zou J, Rohde E, Wittmann M, Kumaravel G, Rhodes KJ, Scannevin RH, Dunah AW, Guckian KM. Lin EYS, et al. Among authors: guckian km. Sci Rep. 2018 Sep 7;8(1):13438. doi: 10.1038/s41598-018-31680-3. Sci Rep. 2018. PMID: 30194389 Free PMC article.
Novel Potent Selective Orally Active S1P5 Receptor Antagonists.
Ma B, Guckian KM, Liu XG, Yang C, Li B, Scannevin R, Mingueneau M, Drouillard A, Walzer T. Ma B, et al. Among authors: guckian km. ACS Med Chem Lett. 2021 Jan 15;12(3):351-355. doi: 10.1021/acsmedchemlett.0c00631. eCollection 2021 Mar 11. ACS Med Chem Lett. 2021. PMID: 33738061 Free PMC article.
Synapto-depressive effects of amyloid beta require PICK1.
Alfonso S, Kessels HW, Banos CC, Chan TR, Lin ET, Kumaravel G, Scannevin RH, Rhodes KJ, Huganir R, Guckian KM, Dunah AW, Malinow R. Alfonso S, et al. Among authors: guckian km. Eur J Neurosci. 2014 Apr;39(7):1225-33. doi: 10.1111/ejn.12499. Eur J Neurosci. 2014. PMID: 24713001 Free PMC article.
Development of a PET Tracer for OGA with Improved Kinetics in the Living Brain.
Cook BE, Nag S, Arakawa R, Lin EY, Stratman N, Guckian K, Hering H, Lulla M, Choi J, Salinas C, Genung NE, Morén AF, Bolin M, Boscutti G, Plisson C, Martarello L, Halldin C, Kaliszczak MA. Cook BE, et al. J Nucl Med. 2023 Oct;64(10):1588-1593. doi: 10.2967/jnumed.122.265225. Epub 2023 Jul 6. J Nucl Med. 2023. PMID: 37934021
28 results