Kumaravel G - Search Results

1

Stereochemistry-activity relationship of orally active tetralin S1P agonist prodrugs.

Ma B, Guckian KM, Lin EY, Lee WC, Scott D, Kumaravel G, Macdonald TL, Lynch KR, Black C, Chollate S, Hahm K, Hetu G, Jin P, Luo Y, Rohde E, Rossomando A, Scannevin R, Wang J, Yang C. Ma B, et al. Among authors: kumaravel g. Bioorg Med Chem Lett. 2010 Apr 1;20(7):2264-9. doi: 10.1016/j.bmcl.2010.02.006. Epub 2010 Feb 6. Bioorg Med Chem Lett. 2010. PMID: 20188554 Free PMC article.

2

Piperazine derivatives of [1,2,4]triazolo[1,5-a][1,3,5]triazine as potent and selective adenosine A2a receptor antagonists.

Vu CB, Peng B, Kumaravel G, Smits G, Jin X, Phadke D, Engber T, Huang C, Reilly J, Tam S, Grant D, Hetu G, Chen L, Zhang J, Petter RC. Vu CB, et al. Among authors: kumaravel g. J Med Chem. 2004 Aug 12;47(17):4291-9. doi: 10.1021/jm0498405. J Med Chem. 2004. PMID: 15294001

3

Discovery of 4-aminomethylphenylacetic acids as γ-secretase modulators via a scaffold design approach.

Xin Z, Peng H, Zhang A, Talreja T, Kumaravel G, Xu L, Rohde E, Jung MY, Shackett MN, Kocisko D, Chollate S, Dunah AW, Snodgrass-Belt PA, Arnold HM, Taveras AG, Rhodes KJ, Scannevin RH. Xin Z, et al. Among authors: kumaravel g. Bioorg Med Chem Lett. 2011 Dec 15;21(24):7277-80. doi: 10.1016/j.bmcl.2011.10.047. Epub 2011 Oct 19. Bioorg Med Chem Lett. 2011. PMID: 22061640

4

Novel diamino derivatives of [1,2,4]triazolo[1,5-a][1,3,5]triazine as potent and selective adenosine A2a receptor antagonists.

Vu CB, Pan D, Peng B, Kumaravel G, Smits G, Jin X, Phadke D, Engber T, Huang C, Reilly J, Tam S, Grant D, Hetu G, Petter RC. Vu CB, et al. Among authors: kumaravel g. J Med Chem. 2005 Mar 24;48(6):2009-18. doi: 10.1021/jm0498396. J Med Chem. 2005. PMID: 15771443

5

Discovery of BIIB042, a Potent, Selective, and Orally Bioavailable γ-Secretase Modulator.

Peng H, Talreja T, Xin Z, Cuervo JH, Kumaravel G, Humora MJ, Xu L, Rohde E, Gan L, Jung MY, Shackett MN, Chollate S, Dunah AW, Snodgrass-Belt PA, Arnold HM, Taveras AG, Rhodes KJ, Scannevin RH. Peng H, et al. Among authors: kumaravel g. ACS Med Chem Lett. 2011 Aug 5;2(10):786-91. doi: 10.1021/ml200175q. eCollection 2011 Oct 13. ACS Med Chem Lett. 2011. PMID: 24900267 Free PMC article.

6

Synthesis of alkyne derivatives of a novel triazolopyrazine as A(2A) adenosine receptor antagonists.

Yao G, Haque S, Sha L, Kumaravel G, Wang J, Engber TM, Whalley ET, Conlon PR, Chang H, Kiesman WF, Petter RC. Yao G, et al. Among authors: kumaravel g. Bioorg Med Chem Lett. 2005 Feb 1;15(3):511-5. doi: 10.1016/j.bmcl.2004.11.062. Bioorg Med Chem Lett. 2005. PMID: 15664803

7

Synthesis of [1,2,4]triazolo[1,5-a]pyrazines as adenosine A2A receptor antagonists.

Dowling JE, Vessels JT, Haque S, Chang HX, van Vloten K, Kumaravel G, Engber T, Jin X, Phadke D, Wang J, Ayyub E, Petter RC. Dowling JE, et al. Among authors: kumaravel g. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4809-13. doi: 10.1016/j.bmcl.2005.07.052. Bioorg Med Chem Lett. 2005. PMID: 16153830

8

Triamino derivatives of triazolotriazine and triazolopyrimidine as adenosine A2a receptor antagonists.

Vu CB, Shields P, Peng B, Kumaravel G, Jin X, Phadke D, Wang J, Engber T, Ayyub E, Petter RC. Vu CB, et al. Among authors: kumaravel g. Bioorg Med Chem Lett. 2004 Oct 4;14(19):4835-8. doi: 10.1016/j.bmcl.2004.07.048. Bioorg Med Chem Lett. 2004. PMID: 15341934

9

Novel bicyclic piperazine derivatives of triazolotriazine and triazolopyrimidines as highly potent and selective adenosine A2A receptor antagonists.

Peng H, Kumaravel G, Yao G, Sha L, Wang J, Van Vlijmen H, Bohnert T, Huang C, Vu CB, Ensinger CL, Chang H, Engber TM, Whalley ET, Petter RC. Peng H, et al. Among authors: kumaravel g. J Med Chem. 2004 Dec 2;47(25):6218-29. doi: 10.1021/jm0494321. J Med Chem. 2004. PMID: 15566292

10

BIIB042, a novel γ-secretase modulator, reduces amyloidogenic Aβ isoforms in primates and rodents and plaque pathology in a mouse model of Alzheimer's disease.

Scannevin RH, Chollate S, Brennan MS, Snodgrass-Belt PA, Peng H, Xu L, Jung MY, Bussiere T, Arastu MF, Talreja T, Xin Z, Dunstan RW, Fahrer D, Rohde E, Dunah AW, Wang J, Kumaravel G, Taveras AG, Moore Arnold H, Rhodes KJ. Scannevin RH, et al. Among authors: kumaravel g. Neuropharmacology. 2016 Apr;103:57-68. doi: 10.1016/j.neuropharm.2015.12.006. Epub 2015 Dec 12. Neuropharmacology. 2016. PMID: 26690893

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