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DNA sequences proximal to human mitochondrial DNA deletion breakpoints prevalent in human disease form G-quadruplexes, a class of DNA structures inefficiently unwound by the mitochondrial replicative Twinkle helicase.
Bharti SK, Sommers JA, Zhou J, Kaplan DL, Spelbrink JN, Mergny JL, Brosh RM Jr. Bharti SK, et al. Among authors: mergny jl. J Biol Chem. 2014 Oct 24;289(43):29975-93. doi: 10.1074/jbc.M114.567073. Epub 2014 Sep 5. J Biol Chem. 2014. PMID: 25193669 Free PMC article.
The role of G-Quadruplex DNA in Paraspeckle formation in cancer.
Bhatt U, Kretzmann AL, Guédin A, Ou A, Kobelke S, Bond CS, Evans CW, Hurley LH, Mergny JL, Iyer KS, Fox AH, Smith NM. Bhatt U, et al. Among authors: mergny jl. Biochimie. 2021 Nov;190:124-131. doi: 10.1016/j.biochi.2021.07.008. Epub 2021 Jul 27. Biochimie. 2021. PMID: 34329720
Re-evaluation of G-quadruplex propensity with G4Hunter.
Bedrat A, Lacroix L, Mergny JL. Bedrat A, et al. Among authors: mergny jl. Nucleic Acids Res. 2016 Feb 29;44(4):1746-59. doi: 10.1093/nar/gkw006. Epub 2016 Jan 20. Nucleic Acids Res. 2016. PMID: 26792894 Free PMC article.
Telomerase inhibitors based on quadruplex ligands selected by a fluorescence assay.
Mergny JL, Lacroix L, Teulade-Fichou MP, Hounsou C, Guittat L, Hoarau M, Arimondo PB, Vigneron JP, Lehn JM, Riou JF, Garestier T, Hélène C. Mergny JL, et al. Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3062-7. doi: 10.1073/pnas.051620698. Proc Natl Acad Sci U S A. 2001. PMID: 11248032 Free PMC article.
309 results