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Synthesis and SAR of heterocyclic carboxylic acid isosteres based on 2-biarylethylimidazole as bombesin receptor subtype-3 (BRS-3) agonists for the treatment of obesity.
Bioorg Med Chem Lett. 2010 May 1;20(9):2912-5. doi: 10.1016/j.bmcl.2010.03.028. Epub 2010 Mar 12.
Bioorg Med Chem Lett. 2010.
PMID: 20347296
Discovery of substituted biphenyl imidazoles as potent, bioavailable bombesin receptor subtype-3 agonists.
He S, Dobbelaar PH, Liu J, Jian T, Sebhat IK, Lin LS, Goodman A, Guo C, Guzzo PR, Hadden M, Henderson AJ, Ruenz M, Sargent BJ, Yet L, Kelly TM, Palyha O, Kan Y, Pan J, Chen H, Marsh DJ, Shearman LP, Strack AM, Metzger JM, Feighner SD, Tan C, Howard AD, Tamvakopoulos C, Peng Q, Guan XM, Reitman ML, Patchett AA, Wyvratt MJ Jr, Nargund RP.
He S, et al. Among authors: ruenz m.
Bioorg Med Chem Lett. 2010 Mar 15;20(6):1913-7. doi: 10.1016/j.bmcl.2010.01.154. Epub 2010 Feb 4.
Bioorg Med Chem Lett. 2010.
PMID: 20167483
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Synthesis and SAR of derivatives based on 2-biarylethylimidazole as bombesin receptor subtype-3 (BRS-3) agonists for the treatment of obesity.
Liu J, He S, Jian T, Dobbelaar PH, Sebhat IK, Lin LS, Goodman A, Guo C, Guzzo PR, Hadden M, Henderson AJ, Pattamana K, Ruenz M, Sargent BJ, Swenson B, Yet L, Tamvakopoulos C, Peng Q, Pan J, Kan Y, Palyha O, Kelly TM, Guan XM, Howard AD, Marsh DJ, Metzger JM, Reitman ML, Wyvratt MJ, Nargund RP.
Liu J, et al. Among authors: ruenz m.
Bioorg Med Chem Lett. 2010 Apr 1;20(7):2074-7. doi: 10.1016/j.bmcl.2010.02.076. Epub 2010 Feb 21.
Bioorg Med Chem Lett. 2010.
PMID: 20219372
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Kinetics of hydrolysis of 8-(arylamino)-2'-deoxyguanosines.
Novak M, Ruenz M, Kazerani S, Toth K, Nguyen TM, Heinrich B.
Novak M, et al. Among authors: ruenz m.
J Org Chem. 2002 Apr 5;67(7):2303-8. doi: 10.1021/jo0163492.
J Org Chem. 2002.
PMID: 11925245
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Sustained Human Background Exposure to Acrolein Evidenced by Monitoring Urinary Exposure Biomarkers.
Ruenz M, Goerke K, Bakuradze T, Abraham K, Lampen A, Eisenbrand G, Richling E.
Ruenz M, et al.
Mol Nutr Food Res. 2019 Dec;63(24):e1900849. doi: 10.1002/mnfr.201900849. Epub 2019 Dec 3.
Mol Nutr Food Res. 2019.
PMID: 31752044
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Biomonitoring of nutritional acrylamide intake by consumers without dietary preferences as compared to vegans.
Goerke K, Ruenz M, Lampen A, Abraham K, Bakuradze T, Eisenbrand G, Richling E.
Goerke K, et al. Among authors: ruenz m.
Arch Toxicol. 2019 Apr;93(4):987-996. doi: 10.1007/s00204-019-02412-x. Epub 2019 Feb 20.
Arch Toxicol. 2019.
PMID: 30788551
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Biomarker monitoring of controlled dietary acrylamide exposure indicates consistent human endogenous background.
Goempel K, Tedsen L, Ruenz M, Bakuradze T, Schipp D, Galan J, Eisenbrand G, Richling E.
Goempel K, et al. Among authors: ruenz m.
Arch Toxicol. 2017 Nov;91(11):3551-3560. doi: 10.1007/s00204-017-1990-1. Epub 2017 May 22.
Arch Toxicol. 2017.
PMID: 28534225
Free PMC article.
Clinical Trial.
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Monitoring urinary mercapturic acids as biomarkers of human dietary exposure to acrylamide in combination with acrylamide uptake assessment based on duplicate diets.
Ruenz M, Bakuradze T, Eisenbrand G, Richling E.
Ruenz M, et al.
Arch Toxicol. 2016 Apr;90(4):873-81. doi: 10.1007/s00204-015-1494-9. Epub 2015 Mar 11.
Arch Toxicol. 2016.
PMID: 25757395
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