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Simple and selective method for the determination of various tyrosine kinase inhibitors used in the clinical setting by liquid chromatography tandem mass spectrometry.
Honeywell R, Yarzadah K, Giovannetti E, Losekoot N, Smit EF, Walraven M, Lind JS, Tibaldi C, Verheul HM, Peters GJ. Honeywell R, et al. Among authors: losekoot n. J Chromatogr B Analyt Technol Biomed Life Sci. 2010 May 1;878(15-16):1059-68. doi: 10.1016/j.jchromb.2010.03.010. Epub 2010 Mar 15. J Chromatogr B Analyt Technol Biomed Life Sci. 2010. PMID: 20382575
Selection of the best blood compartment to measure cytidine deaminase activity to stratify for optimal gemcitabine or cytarabine treatment.
Peters GJ, Honeywell RJ, Maulandi M, Giovannetti E, Losekoot N, Etienne-Grimaldi MC, Milano G, Serdjebi C, Ciccolini J; EORTC-Pharmacology and Molecular Mechanism Group. Peters GJ, et al. Among authors: losekoot n. Nucleosides Nucleotides Nucleic Acids. 2014;33(4-6):403-12. doi: 10.1080/15257770.2014.894196. Nucleosides Nucleotides Nucleic Acids. 2014. PMID: 24940698
Trifluorothymidine resistance is associated with decreased thymidine kinase and equilibrative nucleoside transporter expression or increased secretory phospholipase A2.
Temmink OH, Bijnsdorp IV, Prins HJ, Losekoot N, Adema AD, Smid K, Honeywell RJ, Ylstra B, Eijk PP, Fukushima M, Peters GJ. Temmink OH, et al. Among authors: losekoot n. Mol Cancer Ther. 2010 Apr;9(4):1047-57. doi: 10.1158/1535-7163.MCT-09-0932. Epub 2010 Apr 6. Mol Cancer Ther. 2010. PMID: 20371715
The effect of allopurinol and low-dose thiopurine combination therapy on the activity of three pivotal thiopurine metabolizing enzymes: results from a prospective pharmacological study.
Seinen ML, van Asseldonk DP, de Boer NK, Losekoot N, Smid K, Mulder CJ, Bouma G, Peters GJ, van Bodegraven AA. Seinen ML, et al. Among authors: losekoot n. J Crohns Colitis. 2013 Nov;7(10):812-9. doi: 10.1016/j.crohns.2012.12.006. Epub 2013 Jan 11. J Crohns Colitis. 2013. PMID: 23317929
13 results