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The ATG16L1 risk allele associated with Crohn's disease results in a Rac1-dependent defect in dendritic cell migration that is corrected by thiopurines.
Wildenberg ME, Koelink PJ, Diederen K, Te Velde AA, Wolfkamp SC, Nuij VJ, Peppelenbosch MP, Nobis M, Sansom OJ, Anderson KI, van der Woude CJ, D'Haens GR, van den Brink GR. Wildenberg ME, et al. Among authors: te velde aa. Mucosal Immunol. 2017 Mar;10(2):352-360. doi: 10.1038/mi.2016.65. Epub 2016 Jul 20. Mucosal Immunol. 2017. PMID: 27435106 Free article.
Profoundly Expanded T-cell Clones in the Inflamed and Uninflamed Intestine of Patients With Crohn's Disease.
Doorenspleet ME, Westera L, Peters CP, Hakvoort TBM, Esveldt RE, Vogels E, van Kampen AHC, Baas F, Buskens C, Bemelman WA, D'Haens G, Ponsioen CY, Te Velde AA, de Vries N, van den Brink GR. Doorenspleet ME, et al. Among authors: te velde aa. J Crohns Colitis. 2017 Jul 1;11(7):831-839. doi: 10.1093/ecco-jcc/jjx012. J Crohns Colitis. 2017. PMID: 28158397
Anti-TNF therapy in IBD exerts its therapeutic effect through macrophage IL-10 signalling.
Koelink PJ, Bloemendaal FM, Li B, Westera L, Vogels EWM, van Roest M, Gloudemans AK, van 't Wout AB, Korf H, Vermeire S, Te Velde AA, Ponsioen CY, D'Haens GR, Verbeek JS, Geiger TL, Wildenberg ME, van den Brink GR. Koelink PJ, et al. Among authors: te velde aa. Gut. 2020 Jun;69(6):1053-1063. doi: 10.1136/gutjnl-2019-318264. Epub 2019 Sep 10. Gut. 2020. PMID: 31506328 Free PMC article.
TNF-anti-TNF Immune Complexes Inhibit IL-12/IL-23 Secretion by Inflammatory Macrophages via an Fc-dependent Mechanism.
Bloemendaal FM, Koelink PJ, van Schie KA, Rispens T, Peters CP, Buskens CJ, van der Bilt JD, Bemelman WA, Korf H, Sabino JG, Ponsioen CY, Te Velde AA, D'Haens GRAM, Vermeire S, van den Brink GR, Wildenberg ME. Bloemendaal FM, et al. Among authors: te velde aa. J Crohns Colitis. 2018 Aug 29;12(9):1122-1130. doi: 10.1093/ecco-jcc/jjy075. J Crohns Colitis. 2018. PMID: 29860435
miR-511-3p, embedded in the macrophage mannose receptor gene, contributes to intestinal inflammation.
Heinsbroek SE, Squadrito ML, Schilderink R, Hilbers FW, Verseijden C, Hofmann M, Helmke A, Boon L, Wildenberg ME, Roelofs JJ, Ponsioen CY, Peters CP, Te Velde AA, Gordon S, De Palma M, de Jonge WJ. Heinsbroek SE, et al. Among authors: te velde aa. Mucosal Immunol. 2016 Jul;9(4):960-73. doi: 10.1038/mi.2015.113. Epub 2015 Nov 4. Mucosal Immunol. 2016. PMID: 26530135 Free article.
139 results