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Promotion of CHIP-mediated p53 degradation protects the heart from ischemic injury.
Naito AT, Okada S, Minamino T, Iwanaga K, Liu ML, Sumida T, Nomura S, Sahara N, Mizoroki T, Takashima A, Akazawa H, Nagai T, Shiojima I, Komuro I. Naito AT, et al. Among authors: takashima a. Circ Res. 2010 Jun 11;106(11):1692-702. doi: 10.1161/CIRCRESAHA.109.214346. Epub 2010 Apr 22. Circ Res. 2010. PMID: 20413784
In vivo evidence of CHIP up-regulation attenuating tau aggregation.
Sahara N, Murayama M, Mizoroki T, Urushitani M, Imai Y, Takahashi R, Murata S, Tanaka K, Takashima A. Sahara N, et al. Among authors: takashima a. J Neurochem. 2005 Sep;94(5):1254-63. doi: 10.1111/j.1471-4159.2005.03272.x. J Neurochem. 2005. PMID: 16111477 Free article.
Aluminum induces tau aggregation in vitro but not in vivo.
Mizoroki T, Meshitsuka S, Maeda S, Murayama M, Sahara N, Takashima A. Mizoroki T, et al. Among authors: takashima a. J Alzheimers Dis. 2007 Jul;11(4):419-27. doi: 10.3233/jad-2007-11401. J Alzheimers Dis. 2007. PMID: 17656819
GSK-3beta is required for memory reconsolidation in adult brain.
Kimura T, Yamashita S, Nakao S, Park JM, Murayama M, Mizoroki T, Yoshiike Y, Sahara N, Takashima A. Kimura T, et al. Among authors: takashima a. PLoS One. 2008;3(10):e3540. doi: 10.1371/journal.pone.0003540. Epub 2008 Oct 28. PLoS One. 2008. PMID: 18958152 Free PMC article.
Enzymatic characteristics of I213T mutant presenilin-1/gamma-secretase in cell models and knock-in mouse brains: familial Alzheimer disease-linked mutation impairs gamma-site cleavage of amyloid precursor protein C-terminal fragment beta.
Shimojo M, Sahara N, Mizoroki T, Funamoto S, Morishima-Kawashima M, Kudo T, Takeda M, Ihara Y, Ichinose H, Takashima A. Shimojo M, et al. Among authors: takashima a. J Biol Chem. 2008 Jun 13;283(24):16488-96. doi: 10.1074/jbc.M801279200. Epub 2008 Apr 21. J Biol Chem. 2008. PMID: 18430735 Free article.
731 results