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PI3K pathway-directed therapeutic strategies in cancer.
Agarwal R, Carey M, Hennessy B, Mills GB. Agarwal R, et al. Among authors: mills gb. Curr Opin Investig Drugs. 2010 Jun;11(6):615-28. Curr Opin Investig Drugs. 2010. PMID: 20496256 Review.
Exploiting the PI3K/AKT pathway for cancer drug discovery.
Hennessy BT, Smith DL, Ram PT, Lu Y, Mills GB. Hennessy BT, et al. Among authors: mills gb. Nat Rev Drug Discov. 2005 Dec;4(12):988-1004. doi: 10.1038/nrd1902. Nat Rev Drug Discov. 2005. PMID: 16341064 Review.
A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer.
Berns K, Horlings HM, Hennessy BT, Madiredjo M, Hijmans EM, Beelen K, Linn SC, Gonzalez-Angulo AM, Stemke-Hale K, Hauptmann M, Beijersbergen RL, Mills GB, van de Vijver MJ, Bernards R. Berns K, et al. Among authors: mills gb. Cancer Cell. 2007 Oct;12(4):395-402. doi: 10.1016/j.ccr.2007.08.030. Cancer Cell. 2007. PMID: 17936563 Free article. Clinical Trial.
Proteomic and transcriptomic profiling reveals a link between the PI3K pathway and lower estrogen-receptor (ER) levels and activity in ER+ breast cancer.
Creighton CJ, Fu X, Hennessy BT, Casa AJ, Zhang Y, Gonzalez-Angulo AM, Lluch A, Gray JW, Brown PH, Hilsenbeck SG, Osborne CK, Mills GB, Lee AV, Schiff R. Creighton CJ, et al. Among authors: mills gb. Breast Cancer Res. 2010;12(3):R40. doi: 10.1186/bcr2594. Epub 2010 Jun 22. Breast Cancer Res. 2010. PMID: 20569503 Free PMC article.
HDAC4-regulated STAT1 activation mediates platinum resistance in ovarian cancer.
Stronach EA, Alfraidi A, Rama N, Datler C, Studd JB, Agarwal R, Guney TG, Gourley C, Hennessy BT, Mills GB, Mai A, Brown R, Dina R, Gabra H. Stronach EA, et al. Among authors: mills gb. Cancer Res. 2011 Jul 1;71(13):4412-22. doi: 10.1158/0008-5472.CAN-10-4111. Epub 2011 May 13. Cancer Res. 2011. PMID: 21571862 Free PMC article.
Functional proteomic analysis of advanced serous ovarian cancer using reverse phase protein array: TGF-beta pathway signaling indicates response to primary chemotherapy.
Carey MS, Agarwal R, Gilks B, Swenerton K, Kalloger S, Santos J, Ju Z, Lu Y, Zhang F, Coombes KR, Miller D, Huntsman D, Mills GB, Hennessy BT. Carey MS, et al. Among authors: mills gb. Clin Cancer Res. 2010 May 15;16(10):2852-60. doi: 10.1158/1078-0432.CCR-09-2502. Epub 2010 May 11. Clin Cancer Res. 2010. PMID: 20460476 Free PMC article.
Pharmacodynamic markers of perifosine efficacy.
Hennessy BT, Lu Y, Poradosu E, Yu Q, Yu S, Hall H, Carey MS, Ravoori M, Gonzalez-Angulo AM, Birch R, Henderson IC, Kundra V, Mills GB. Hennessy BT, et al. Among authors: mills gb. Clin Cancer Res. 2007 Dec 15;13(24):7421-31. doi: 10.1158/1078-0432.CCR-07-0760. Clin Cancer Res. 2007. PMID: 18094426
1,137 results