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The unique hypusine modification of eIF5A promotes islet beta cell inflammation and dysfunction in mice.
Maier B, Ogihara T, Trace AP, Tersey SA, Robbins RD, Chakrabarti SK, Nunemaker CS, Stull ND, Taylor CA, Thompson JE, Dondero RS, Lewis EC, Dinarello CA, Nadler JL, Mirmira RG. Maier B, et al. Among authors: dinarello ca. J Clin Invest. 2010 Jun;120(6):2156-70. doi: 10.1172/JCI38924. Epub 2010 May 24. J Clin Invest. 2010. PMID: 20501948 Free PMC article.
Alpha1-antitrypsin monotherapy prolongs islet allograft survival in mice.
Lewis EC, Shapiro L, Bowers OJ, Dinarello CA. Lewis EC, et al. Among authors: dinarello ca. Proc Natl Acad Sci U S A. 2005 Aug 23;102(34):12153-8. doi: 10.1073/pnas.0505579102. Epub 2005 Aug 10. Proc Natl Acad Sci U S A. 2005. PMID: 16093309 Free PMC article.
α1-Antitrypsin therapy downregulates toll-like receptor-induced IL-1β responses in monocytes and myeloid dendritic cells and may improve islet function in recently diagnosed patients with type 1 diabetes.
Gottlieb PA, Alkanani AK, Michels AW, Lewis EC, Shapiro L, Dinarello CA, Zipris D. Gottlieb PA, et al. Among authors: dinarello ca. J Clin Endocrinol Metab. 2014 Aug;99(8):E1418-26. doi: 10.1210/jc.2013-3864. Epub 2014 Feb 14. J Clin Endocrinol Metab. 2014. PMID: 24527714 Free PMC article. Clinical Trial.
Differences in signaling pathways by IL-1beta and IL-18.
Lee JK, Kim SH, Lewis EC, Azam T, Reznikov LL, Dinarello CA. Lee JK, et al. Among authors: dinarello ca. Proc Natl Acad Sci U S A. 2004 Jun 8;101(23):8815-20. doi: 10.1073/pnas.0402800101. Epub 2004 May 25. Proc Natl Acad Sci U S A. 2004. PMID: 15161979 Free PMC article.
1,090 results