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RNAi-mediated germline knockdown of FABP4 increases body weight but does not improve the deranged nutrient metabolism of diet-induced obese mice.
Yang R, Castriota G, Chen Y, Cleary MA, Ellsworth K, Shin MK, Tran JL, Vogt TF, Wu M, Xu S, Yang X, Zhang BB, Berger JP, Qureshi SA. Yang R, et al. Among authors: wu m. Int J Obes (Lond). 2011 Feb;35(2):217-25. doi: 10.1038/ijo.2010.128. Epub 2010 Jul 6. Int J Obes (Lond). 2011. PMID: 20603627 Free PMC article.
Design and synthesis of a new class of malonyl-CoA decarboxylase inhibitors with anti-obesity and anti-diabetic activities.
Tang H, Yan Y, Feng Z, de Jesus RK, Yang L, Levorse DA, Owens KA, Akiyama TE, Bergeron R, Castriota GA, Doebber TW, Ellsworth KP, Lassman ME, Li C, Wu MS, Zhang BB, Chapman KT, Mills SG, Berger JP, Pasternak A. Tang H, et al. Bioorg Med Chem Lett. 2010 Oct 15;20(20):6088-92. doi: 10.1016/j.bmcl.2010.08.047. Epub 2010 Aug 20. Bioorg Med Chem Lett. 2010. PMID: 20832306
Suppression of PC-1/ENPP-1 expression improves insulin sensitivity in vitro and in vivo.
Zhou HH, Chin CN, Wu M, Ni W, Quan S, Liu F, Dallas-Yang Q, Ellsworth K, Ho T, Zhang A, Natasha T, Li J, Chapman K, Strohl W, Li C, Wang IM, Berger J, An Z, Zhang BB, Jiang G. Zhou HH, et al. Among authors: wu m. Eur J Pharmacol. 2009 Aug 15;616(1-3):346-52. doi: 10.1016/j.ejphar.2009.06.057. Epub 2009 Jul 3. Eur J Pharmacol. 2009. PMID: 19577557
Antidiabetic and antisteatotic effects of the selective fatty acid synthase (FAS) inhibitor platensimycin in mouse models of diabetes.
Wu M, Singh SB, Wang J, Chung CC, Salituro G, Karanam BV, Lee SH, Powles M, Ellsworth KP, Lassman ME, Miller C, Myers RW, Tota MR, Zhang BB, Li C. Wu M, et al. Proc Natl Acad Sci U S A. 2011 Mar 29;108(13):5378-83. doi: 10.1073/pnas.1002588108. Epub 2011 Mar 9. Proc Natl Acad Sci U S A. 2011. PMID: 21389266 Free PMC article.
FGF21 analogs of sustained action enabled by orthogonal biosynthesis demonstrate enhanced antidiabetic pharmacology in rodents.
Mu J, Pinkstaff J, Li Z, Skidmore L, Li N, Myler H, Dallas-Yang Q, Putnam AM, Yao J, Bussell S, Wu M, Norman TC, Rodriguez CG, Kimmel B, Metzger JM, Manibusan A, Lee D, Zaller DM, Zhang BB, DiMarchi RD, Berger JP, Axelrod DW. Mu J, et al. Among authors: wu m. Diabetes. 2012 Feb;61(2):505-12. doi: 10.2337/db11-0838. Epub 2011 Dec 30. Diabetes. 2012. PMID: 22210323 Free PMC article.
Novel peroxisome proliferator-activated receptor (PPAR) gamma and PPARdelta ligands produce distinct biological effects.
Berger J, Leibowitz MD, Doebber TW, Elbrecht A, Zhang B, Zhou G, Biswas C, Cullinan CA, Hayes NS, Li Y, Tanen M, Ventre J, Wu MS, Berger GD, Mosley R, Marquis R, Santini C, Sahoo SP, Tolman RL, Smith RG, Moller DE. Berger J, et al. Among authors: wu ms. J Biol Chem. 1999 Mar 5;274(10):6718-25. doi: 10.1074/jbc.274.10.6718. J Biol Chem. 1999. PMID: 10037770 Free article.
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