Doss GA - Search Results

1

In vitro and in vivo metabolism of a novel cannabinoid-1 receptor inverse agonist, taranabant, in rats and monkeys.

Reddy VB, Doss GA, Karanam BV, Samuel K, Lanza TJ Jr, Lin LS, Yu NX, Zhang AS, Raab CE, Stearns RA, Kumar S. Reddy VB, et al. Among authors: doss ga. Xenobiotica. 2010 Sep;40(9):650-62. doi: 10.3109/00498254.2010.501117. Xenobiotica. 2010. PMID: 20608842

2

Metabolic activation of a pentafluorophenylethylamine derivative: formation of glutathione conjugates in vitro in the rat.

Shang J, Xu S, Teffera Y, Doss GA, Stearns RA, Edmonson S, Beconi MG. Shang J, et al. Among authors: doss ga. Xenobiotica. 2005 Jul;35(7):697-713. doi: 10.1080/00498250500230479. Xenobiotica. 2005. PMID: 16316929

3

Pharmacokinetics, metabolism, and excretion of anacetrapib, a novel inhibitor of the cholesteryl ester transfer protein, in rats and rhesus monkeys.

Tan EY, Hartmann G, Chen Q, Pereira A, Bradley S, Doss G, Zhang AS, Ho JZ, Braun MP, Dean DC, Tang W, Kumar S. Tan EY, et al. Drug Metab Dispos. 2010 Mar;38(3):459-73. doi: 10.1124/dmd.109.028696. Epub 2009 Dec 16. Drug Metab Dispos. 2010. PMID: 20016052

4

Metabolism of a thiazole benzenesulfonamide derivative, a potent and elective agonist of the human beta3-adrenergic receptor, in rats: identification of a novel isethionic acid conjugate.

Tang W, Stearns RA, Miller RR, Ngui JS, Mathvink RJ, Weber AE, Kwei GY, Strauss JR, Keohane CA, Doss GA, Chiu SH, Baillie TA. Tang W, et al. Among authors: doss ga. Drug Metab Dispos. 2002 Jul;30(7):778-87. doi: 10.1124/dmd.30.7.778. Drug Metab Dispos. 2002. PMID: 12065436

5

A novel P450-catalyzed transformation of the 2,2,6,6-tetramethyl piperidine moiety to a 2,2-dimethyl pyrrolidine in human liver microsomes: characterization by high resolution quadrupole-time-of-flight mass spectrometry and 1H-NMR.

Yin W, Doss GA, Stearns RA, Chaudhary AG, Hop CE, Franklin RB, Kumar S. Yin W, et al. Among authors: doss ga. Drug Metab Dispos. 2003 Feb;31(2):215-23. doi: 10.1124/dmd.31.2.215. Drug Metab Dispos. 2003. PMID: 12527703

6

N-acetylation of the glutamate residue of intact glutathione conjugates in rats: a novel pathway for the metabolic processing of thiol adducts of xenobiotics.

Yin W, Doss GA, Stearns RA, Kumar S. Yin W, et al. Among authors: doss ga. Drug Metab Dispos. 2004 Jan;32(1):43-8. doi: 10.1124/dmd.32.1.43. Drug Metab Dispos. 2004. PMID: 14709619

7

Identification of a hydroxylamine glucuronide metabolite of an oral hypoglycemic agent.

Miller RR, Doss GA, Stearns RA. Miller RR, et al. Among authors: doss ga. Drug Metab Dispos. 2004 Feb;32(2):178-85. doi: 10.1124/dmd.32.2.178. Drug Metab Dispos. 2004. PMID: 14744939

8

Identification and metabolism of a novel dihydrohydroxy-S-glutathionyl conjugate of a peroxisome proliferator-activated receptor agonist, MK-0767 [(+/-)-5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-methoxy-N-[[(4-trifluoromethyl) phenyl]methyl]benzamide], in rats.

Reddy VB, Doss GA, Creighton M, Kochansky CJ, Vincent SH, Franklin RB, Karanam BV. Reddy VB, et al. Among authors: doss ga. Drug Metab Dispos. 2004 Oct;32(10):1154-61. doi: 10.1124/dmd.104.000240. Epub 2004 Jun 30. Drug Metab Dispos. 2004. PMID: 15229171

9

In vitro metabolism of MK-0767 [(+/-)-5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-methoxy-N-[[(4-trifluoromethyl)-phenyl] methyl]benzamide], a peroxisome proliferator-activated receptor alpha/gamma agonist. II. Identification of metabolites by liquid chromatography-tandem mass spectrometry.

Liu DQ, Karanam BV, Doss GA, Sidler RR, Vincent SH, Hop CE. Liu DQ, et al. Among authors: doss ga. Drug Metab Dispos. 2004 Sep;32(9):1023-31. doi: 10.1124/dmd.104.000059. Drug Metab Dispos. 2004. PMID: 15319345

10

Evidence for the bioactivation of zomepirac and tolmetin by an oxidative pathway: identification of glutathione adducts in vitro in human liver microsomes and in vivo in rats.

Chen Q, Doss GA, Tung EC, Liu W, Tang YS, Braun MP, Didolkar V, Strauss JR, Wang RW, Stearns RA, Evans DC, Baillie TA, Tang W. Chen Q, et al. Among authors: doss ga. Drug Metab Dispos. 2006 Jan;34(1):145-51. doi: 10.1124/dmd.105.004341. Epub 2005 Oct 26. Drug Metab Dispos. 2006. PMID: 16251255

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