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Analogues of 4-[(7-Bromo-2-methyl-4-oxo-3H-quinazolin-6-yl)methylprop-2-ynylamino]-N-(3-pyridylmethyl)benzamide (CB-30865) as potent inhibitors of nicotinamide phosphoribosyltransferase (Nampt).
Lockman JW, Murphy BR, Zigar DF, Judd WR, Slattum PM, Gao ZH, Ostanin K, Green J, McKinnon R, Terry-Lorenzo RT, Fleischer TC, Boniface JJ, Shenderovich M, Willardsen JA. Lockman JW, et al. Among authors: mckinnon r. J Med Chem. 2010 Dec 23;53(24):8734-46. doi: 10.1021/jm101145b. Epub 2010 Nov 16. J Med Chem. 2010. PMID: 21080724
Characterization of the cellular and antitumor effects of MPI-0479605, a small-molecule inhibitor of the mitotic kinase Mps1.
Tardif KD, Rogers A, Cassiano J, Roth BL, Cimbora DM, McKinnon R, Peterson A, Douce TB, Robinson R, Dorweiler I, Davis T, Hess MA, Ostanin K, Papac DI, Baichwal V, McAlexander I, Willardsen JA, Saunders M, Christophe H, Kumar DV, Wettstein DA, Carlson RO, Williams BL. Tardif KD, et al. Among authors: mckinnon r. Mol Cancer Ther. 2011 Dec;10(12):2267-75. doi: 10.1158/1535-7163.MCT-11-0453. Epub 2011 Oct 6. Mol Cancer Ther. 2011. PMID: 21980130
Lead optimization of purine based orally bioavailable Mps1 (TTK) inhibitors.
Vijay Kumar D, Hoarau C, Bursavich M, Slattum P, Gerrish D, Yager K, Saunders M, Shenderovich M, Roth BL, McKinnon R, Chan A, Cimbora DM, Bradford C, Reeves L, Patton S, Papac DI, Williams BL, Carlson RO. Vijay Kumar D, et al. Among authors: mckinnon r. Bioorg Med Chem Lett. 2012 Jul 1;22(13):4377-85. doi: 10.1016/j.bmcl.2012.04.131. Epub 2012 May 5. Bioorg Med Chem Lett. 2012. PMID: 22632936
Discovery of (2S)-1-[4-(2-{6-amino-8-[(6-bromo-1,3-benzodioxol-5-yl)sulfanyl]-9H-purin-9-yl}ethyl)piperidin-1-yl]-2-hydroxypropan-1-one (MPC-3100), a purine-based Hsp90 inhibitor.
Kim SH, Bajji A, Tangallapally R, Markovitz B, Trovato R, Shenderovich M, Baichwal V, Bartel P, Cimbora D, McKinnon R, Robinson R, Papac D, Wettstein D, Carlson R, Yager KM. Kim SH, et al. Among authors: mckinnon r. J Med Chem. 2012 Sep 13;55(17):7480-501. doi: 10.1021/jm3004619. Epub 2012 Aug 31. J Med Chem. 2012. PMID: 22913511
Triterpene based compounds with potent anti-maturation activity against HIV-1.
Gerrish D, Kim IC, Kumar DV, Austin H, Garrus JE, Baichwal V, Saunders M, McKinnon RS, Anderson MB, Carlson R, Arranz-Plaza E, Yager KM. Gerrish D, et al. Among authors: mckinnon rs. Bioorg Med Chem Lett. 2008 Dec 15;18(24):6377-80. doi: 10.1016/j.bmcl.2008.10.098. Epub 2008 Oct 25. Bioorg Med Chem Lett. 2008. PMID: 18996008
Design and characterization of ebolavirus GP prehairpin intermediate mimics as drug targets.
Clinton TR, Weinstock MT, Jacobsen MT, Szabo-Fresnais N, Pandya MJ, Whitby FG, Herbert AS, Prugar LI, McKinnon R, Hill CP, Welch BD, Dye JM, Eckert DM, Kay MS. Clinton TR, et al. Among authors: mckinnon r. Protein Sci. 2015 Apr;24(4):446-63. doi: 10.1002/pro.2578. Epub 2014 Oct 31. Protein Sci. 2015. PMID: 25287718 Free PMC article.
314 results