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Endothelial alpha3beta1-integrin represses pathological angiogenesis and sustains endothelial-VEGF.
da Silva RG, Tavora B, Robinson SD, Reynolds LE, Szekeres C, Lamar J, Batista S, Kostourou V, Germain MA, Reynolds AR, Jones DT, Watson AR, Jones JL, Harris A, Hart IR, Iruela-Arispe ML, Dipersio CM, Kreidberg JA, Hodivala-Dilke KM. da Silva RG, et al. Among authors: hart ir. Am J Pathol. 2010 Sep;177(3):1534-48. doi: 10.2353/ajpath.2010.100043. Epub 2010 Jul 16. Am J Pathol. 2010. PMID: 20639457 Free PMC article.
Endothelial FAK is required for tumour angiogenesis.
Tavora B, Batista S, Reynolds LE, Jadeja S, Robinson S, Kostourou V, Hart I, Fruttiger M, Parsons M, Hodivala-Dilke KM. Tavora B, et al. EMBO Mol Med. 2010 Dec;2(12):516-28. doi: 10.1002/emmm.201000106. EMBO Mol Med. 2010. PMID: 21154724 Free PMC article.
Tumour angiogenesis is reduced in the Tc1 mouse model of Down's syndrome.
Reynolds LE, Watson AR, Baker M, Jones TA, D'Amico G, Robinson SD, Joffre C, Garrido-Urbani S, Rodriguez-Manzaneque JC, Martino-Echarri E, Aurrand-Lions M, Sheer D, Dagna-Bricarelli F, Nizetic D, McCabe CJ, Turnell AS, Kermorgant S, Imhof BA, Adams R, Fisher EM, Tybulewicz VL, Hart IR, Hodivala-Dilke KM. Reynolds LE, et al. Among authors: hart ir. Nature. 2010 Jun 10;465(7299):813-7. doi: 10.1038/nature09106. Nature. 2010. PMID: 20535211 Free PMC article.
FAK-heterozygous mice display enhanced tumour angiogenesis.
Kostourou V, Lechertier T, Reynolds LE, Lees DM, Baker M, Jones DT, Tavora B, Ramjaun AR, Birdsey GM, Robinson SD, Parsons M, Randi AM, Hart IR, Hodivala-Dilke K. Kostourou V, et al. Among authors: hart ir. Nat Commun. 2013;4:2020. doi: 10.1038/ncomms3020. Nat Commun. 2013. PMID: 23799510 Free PMC article.
Endothelial FAK is required for tumour angiogenesis.
Tavora B, Batista S, Reynolds LE, Jadeja S, Robinson S, Kostourou V, Hart I, Fruttiger M, Parsons M, Hodivala-Dilke KM. Tavora B, et al. EMBO Mol Med. 2016 Oct 4;8(10):1229. doi: 10.15252/emmm.201606907. Print 2016 Oct. EMBO Mol Med. 2016. PMID: 27702771 Free PMC article.
Clinical and functional significance of α9β1 integrin expression in breast cancer: a novel cell-surface marker of the basal phenotype that promotes tumour cell invasion.
Allen MD, Vaziri R, Green M, Chelala C, Brentnall AR, Dreger S, Vallath S, Nitch-Smith H, Hayward J, Carpenter R, Holliday DL, Walker RA, Hart IR, Jones JL. Allen MD, et al. Among authors: hart ir. J Pathol. 2011 Apr;223(5):646-58. doi: 10.1002/path.2833. Epub 2011 Feb 21. J Pathol. 2011. PMID: 21341269
236 results