Steele NL - Search Results

1

Pharmacokinetic and pharmacodynamic properties of an oral formulation of the histone deacetylase inhibitor Belinostat (PXD101).

Steele NL, Plumb JA, Vidal L, Tjørnelund J, Knoblauch P, Buhl-Jensen P, Molife R, Brown R, de Bono JS, Evans TR. Steele NL, et al. Cancer Chemother Pharmacol. 2011 Jun;67(6):1273-9. doi: 10.1007/s00280-010-1419-5. Epub 2010 Aug 13. Cancer Chemother Pharmacol. 2011. PMID: 20706839 Clinical Trial.

2

Combined inhibition of DNA methylation and histone acetylation enhances gene re-expression and drug sensitivity in vivo.

Steele N, Finn P, Brown R, Plumb JA. Steele N, et al. Br J Cancer. 2009 Mar 10;100(5):758-63. doi: 10.1038/sj.bjc.6604932. Br J Cancer. 2009. PMID: 19259094 Free PMC article.

3

A phase 1 pharmacokinetic and pharmacodynamic study of the histone deacetylase inhibitor belinostat in patients with advanced solid tumors.

Steele NL, Plumb JA, Vidal L, Tjørnelund J, Knoblauch P, Rasmussen A, Ooi CE, Buhl-Jensen P, Brown R, Evans TR, DeBono JS. Steele NL, et al. Clin Cancer Res. 2008 Feb 1;14(3):804-10. doi: 10.1158/1078-0432.CCR-07-1786. Clin Cancer Res. 2008. PMID: 18245542 Clinical Trial.

4

Candidate DNA methylation drivers of acquired cisplatin resistance in ovarian cancer identified by methylome and expression profiling.

Zeller C, Dai W, Steele NL, Siddiq A, Walley AJ, Wilhelm-Benartzi CS, Rizzo S, van der Zee A, Plumb JA, Brown R. Zeller C, et al. Among authors: steele nl. Oncogene. 2012 Oct 18;31(42):4567-76. doi: 10.1038/onc.2011.611. Epub 2012 Jan 16. Oncogene. 2012. PMID: 22249249 Free article.

5

Epigenetic approaches to cancer therapy.

Plumb JA, Steele N, Finn PW, Brown R. Plumb JA, et al. Biochem Soc Trans. 2004 Dec;32(Pt 6):1095-7. doi: 10.1042/BST0321095. Biochem Soc Trans. 2004. PMID: 15506976

6

Vistusertib (dual m-TORC1/2 inhibitor) in combination with paclitaxel in patients with high-grade serous ovarian and squamous non-small-cell lung cancer.

Basu B, Krebs MG, Sundar R, Wilson RH, Spicer J, Jones R, Brada M, Talbot DC, Steele N, Ingles Garces AH, Brugger W, Harrington EA, Evans J, Hall E, Tovey H, de Oliveira FM, Carreira S, Swales K, Ruddle R, Raynaud FI, Purchase B, Dawes JC, Parmar M, Turner AJ, Tunariu N, Banerjee S, de Bono JS, Banerji U. Basu B, et al. Ann Oncol. 2018 Sep 1;29(9):1918-1925. doi: 10.1093/annonc/mdy245. Ann Oncol. 2018. PMID: 30016392 Free PMC article. Clinical Trial.

7

A phase 1 trial of recombinant human IL-21 in combination with cetuximab in patients with metastatic colorectal cancer.

Steele N, Anthony A, Saunders M, Esmarck B, Ehrnrooth E, Kristjansen PE, Nihlén A, Hansen LT, Cassidy J. Steele N, et al. Br J Cancer. 2012 Feb 28;106(5):793-8. doi: 10.1038/bjc.2011.599. Epub 2012 Feb 7. Br J Cancer. 2012. PMID: 22315057 Free PMC article. Clinical Trial.

8

SELECT-3: a phase I study of selumetinib in combination with platinum-doublet chemotherapy for advanced NSCLC in the first-line setting.

Greystoke A, Steele N, Arkenau HT, Blackhall F, Md Haris N, Lindsay CR, Califano R, Voskoboynik M, Summers Y, So K, Ghiorghiu D, Dymond AW, Hossack S, Plummer R, Dean E. Greystoke A, et al. Br J Cancer. 2017 Sep 26;117(7):938-946. doi: 10.1038/bjc.2017.271. Epub 2017 Aug 24. Br J Cancer. 2017. PMID: 28950288 Free PMC article. Clinical Trial.

9

Are patients in clinical trials representative of the general population? Dose intensity and toxicities associated with FE100C-D chemotherapy in a non-trial population of node positive breast cancer patients compared with PACS-01 trial group.

Fraser J, Steele N, Al Zaman A, Yule A. Fraser J, et al. Eur J Cancer. 2011 Jan;47(2):215-20. doi: 10.1016/j.ejca.2010.10.001. Epub 2010 Nov 18. Eur J Cancer. 2011. PMID: 21094038

10

Olaparib as maintenance treatment in patients with chemosensitive small cell lung cancer (STOMP): A randomised, double-blind, placebo-controlled phase II trial.

Woll P, Gaunt P, Danson S, Steele N, Ahmed S, Mulatero C, Shah R, Bhosle J, Hodgkinson E, Watkins B, Billingham L. Woll P, et al. Lung Cancer. 2022 Sep;171:26-33. doi: 10.1016/j.lungcan.2022.07.007. Epub 2022 Jul 15. Lung Cancer. 2022. PMID: 35872530 Free article. Clinical Trial.

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