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Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling.
Ashton GH, Morton JP, Myant K, Phesse TJ, Ridgway RA, Marsh V, Wilkins JA, Athineos D, Muncan V, Kemp R, Neufeld K, Clevers H, Brunton V, Winton DJ, Wang X, Sears RC, Clarke AR, Frame MC, Sansom OJ. Ashton GH, et al. Among authors: wang x. Dev Cell. 2010 Aug 17;19(2):259-69. doi: 10.1016/j.devcel.2010.07.015. Dev Cell. 2010. PMID: 20708588 Free PMC article.
Targeting inhibitors of the tumor suppressor PP2A for the treatment of pancreatic cancer.
Farrell AS, Allen-Petersen B, Daniel CJ, Wang X, Wang Z, Rodriguez S, Impey S, Oddo J, Vitek MP, Lopez C, Christensen DJ, Sheppard B, Sears RC. Farrell AS, et al. Among authors: wang x, wang z. Mol Cancer Res. 2014 Jun;12(6):924-39. doi: 10.1158/1541-7786.MCR-13-0542. Epub 2014 Mar 25. Mol Cancer Res. 2014. PMID: 24667985 Free PMC article.
SUMO protease SENP1 deSUMOylates and stabilizes c-Myc.
Sun XX, Chen Y, Su Y, Wang X, Chauhan KM, Liang J, Daniel CJ, Sears RC, Dai MS. Sun XX, et al. Among authors: wang x. Proc Natl Acad Sci U S A. 2018 Oct 23;115(43):10983-10988. doi: 10.1073/pnas.1802932115. Epub 2018 Oct 10. Proc Natl Acad Sci U S A. 2018. PMID: 30305424 Free PMC article.
Post-translational modification localizes MYC to the nuclear pore basket to regulate a subset of target genes involved in cellular responses to environmental signals.
Su Y, Pelz C, Huang T, Torkenczy K, Wang X, Cherry A, Daniel CJ, Liang J, Nan X, Dai MS, Adey A, Impey S, Sears RC. Su Y, et al. Among authors: wang x. Genes Dev. 2018 Nov 1;32(21-22):1398-1419. doi: 10.1101/gad.314377.118. Epub 2018 Oct 26. Genes Dev. 2018. PMID: 30366908 Free PMC article.
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