Kast R - Search Results

1

Identification and optimization of substituted 5-aminopyrazoles as potent and selective adenosine A1 receptor antagonists.

Griebenow N, Bärfacker L, Meier H, Schneider D, Teusch N, Lustig K, Kast R, Kolkhof P. Griebenow N, et al. Among authors: kast r. Bioorg Med Chem Lett. 2010 Oct 1;20(19):5891-4. doi: 10.1016/j.bmcl.2010.07.095. Epub 2010 Aug 1. Bioorg Med Chem Lett. 2010. PMID: 20728355

2

Novel non-xanthine antagonist of the A_2B adenosine receptor: From HTS hit to lead structure.

Härter M, Kalthof B, Delbeck M, Lustig K, Gerisch M, Schulz S, Kast R, Meibom D, Lindner N. Härter M, et al. Among authors: kast r. Eur J Med Chem. 2019 Feb 1;163:763-778. doi: 10.1016/j.ejmech.2018.11.045. Epub 2018 Nov 20. Eur J Med Chem. 2019. PMID: 30576906

3

Potent and Selective Human Prostaglandin F (FP) Receptor Antagonist (BAY-6672) for the Treatment of Idiopathic Pulmonary Fibrosis (IPF).

Beck H, Thaler T, Meibom D, Meininghaus M, Jörißen H, Dietz L, Terjung C, Bairlein M, von Bühler CJ, Anlauf S, Fürstner C, Stellfeld T, Schneider D, Gericke KM, Buyck T, Lovis K, Münster U, Anlahr J, Kersten E, Levilain G, Marossek V, Kast R. Beck H, et al. Among authors: kast r. J Med Chem. 2020 Oct 22;63(20):11639-11662. doi: 10.1021/acs.jmedchem.0c00834. Epub 2020 Oct 8. J Med Chem. 2020. PMID: 32969660

4

Pharmacological characterization of the first potent and selective antagonist at the cysteinyl leukotriene 2 (CysLT(2)) receptor.

Wunder F, Tinel H, Kast R, Geerts A, Becker EM, Kolkhof P, Hütter J, Ergüden J, Härter M. Wunder F, et al. Among authors: kast r. Br J Pharmacol. 2010 May;160(2):399-409. doi: 10.1111/j.1476-5381.2010.00730.x. Br J Pharmacol. 2010. PMID: 20423349 Free PMC article.

5

Chronic inhibition of phosphodiesterase 5 does not prevent pressure-overload-induced right-ventricular remodelling.

Schäfer S, Ellinghaus P, Janssen W, Kramer F, Lustig K, Milting H, Kast R, Klein M. Schäfer S, et al. Among authors: kast r. Cardiovasc Res. 2009 Apr 1;82(1):30-9. doi: 10.1093/cvr/cvp002. Epub 2009 Jan 8. Cardiovasc Res. 2009. PMID: 19131365

6

Design and synthesis of potent and selective azaindole-based Rho kinase (ROCK) inhibitors.

Schirok H, Kast R, Figueroa-Pérez S, Bennabi S, Gnoth MJ, Feurer A, Heckroth H, Thutewohl M, Paulsen H, Knorr A, Hütter J, Lobell M, Münter K, Geiss V, Ehmke H, Lang D, Radtke M, Mittendorf J, Stasch JP. Schirok H, et al. Among authors: kast r. ChemMedChem. 2008 Dec;3(12):1893-904. doi: 10.1002/cmdc.200800211. ChemMedChem. 2008. PMID: 18973168

7

Neladenoson Bialanate Hydrochloride: A Prodrug of a Partial Adenosine A₁ Receptor Agonist for the Chronic Treatment of Heart Diseases.

Meibom D, Albrecht-Küpper B, Diedrichs N, Hübsch W, Kast R, Krämer T, Krenz U, Lerchen HG, Mittendorf J, Nell PG, Süssmeier F, Vakalopoulos A, Zimmermann K. Meibom D, et al. Among authors: kast r. ChemMedChem. 2017 May 22;12(10):728-737. doi: 10.1002/cmdc.201700151. Epub 2017 May 10. ChemMedChem. 2017. PMID: 28488817

8

Cardiovascular effects of a novel potent and highly selective azaindole-based inhibitor of Rho-kinase.

Kast R, Schirok H, Figueroa-Pérez S, Mittendorf J, Gnoth MJ, Apeler H, Lenz J, Franz JK, Knorr A, Hütter J, Lobell M, Zimmermann K, Münter K, Augstein KH, Ehmke H, Stasch JP. Kast R, et al. Br J Pharmacol. 2007 Dec;152(7):1070-80. doi: 10.1038/sj.bjp.0707484. Epub 2007 Oct 15. Br J Pharmacol. 2007. PMID: 17934515 Free PMC article.

9

Selective attenuation of norepinephrine release and stress-induced heart rate increase by partial adenosine A1 agonism.

Bott-Flügel L, Bernshausen A, Schneider H, Luppa P, Zimmermann K, Albrecht-Küpper B, Kast R, Laugwitz KL, Ehmke H, Knorr A, Seyfarth M. Bott-Flügel L, et al. Among authors: kast r. PLoS One. 2011 Mar 28;6(3):e18048. doi: 10.1371/journal.pone.0018048. PLoS One. 2011. PMID: 21464936 Free PMC article.

10

Generation and characterization of a stable soluble guanylate cyclase-overexpressing CHO cell line.

Becker EM, Wunder F, Kast R, Robyr C, Hoenicka M, Gerzer R, Schröder H, Stasch JP. Becker EM, et al. Among authors: kast r. Nitric Oxide. 1999;3(1):55-66. doi: 10.1006/niox.1999.0207. Nitric Oxide. 1999. PMID: 10355896

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