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Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells.
Rashid ST, Corbineau S, Hannan N, Marciniak SJ, Miranda E, Alexander G, Huang-Doran I, Griffin J, Ahrlund-Richter L, Skepper J, Semple R, Weber A, Lomas DA, Vallier L. Rashid ST, et al. Among authors: griffin j. J Clin Invest. 2010 Sep;120(9):3127-36. doi: 10.1172/JCI43122. Epub 2010 Aug 25. J Clin Invest. 2010. PMID: 20739751 Free PMC article.
Truncation of Pik3r1 causes severe insulin resistance uncoupled from obesity and dyslipidaemia by increased energy expenditure.
Kwok A, Zvetkova I, Virtue S, Luijten I, Huang-Doran I, Tomlinson P, Bulger DA, West J, Murfitt S, Griffin J, Alam R, Hart D, Knox R, Voshol P, Vidal-Puig A, Jensen J, O'Rahilly S, Semple RK. Kwok A, et al. Among authors: griffin j. Mol Metab. 2020 Oct;40:101020. doi: 10.1016/j.molmet.2020.101020. Epub 2020 May 19. Mol Metab. 2020. PMID: 32439336 Free PMC article.
Non-alcoholic fatty liver disease is characterised by a reduced polyunsaturated fatty acid transport via free fatty acids and high-density lipoproteins (HDL).
Mocciaro G, Allison M, Jenkins B, Azzu V, Huang-Doran I, Herrera-Marcos LV, Hall Z, Murgia A, Susan D, Frontini M, Vidal-Puig A, Koulman A, Griffin JL, Vacca M. Mocciaro G, et al. Mol Metab. 2023 Jul;73:101728. doi: 10.1016/j.molmet.2023.101728. Epub 2023 Apr 19. Mol Metab. 2023. PMID: 37084865 Free PMC article.
The GOLIATH Project: Towards an Internationally Harmonised Approach for Testing Metabolism Disrupting Compounds.
Legler J, Zalko D, Jourdan F, Jacobs M, Fromenty B, Balaguer P, Bourguet W, Munic Kos V, Nadal A, Beausoleil C, Cristobal S, Remy S, Ermler S, Margiotta-Casaluci L, Griffin JL, Blumberg B, Chesné C, Hoffmann S, Andersson PL, Kamstra JH. Legler J, et al. Among authors: griffin jl. Int J Mol Sci. 2020 May 14;21(10):3480. doi: 10.3390/ijms21103480. Int J Mol Sci. 2020. PMID: 32423144 Free PMC article.
4,331 results