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The β-blocker atenolol lowers the longevity-related degree of fatty acid unsaturation, decreases protein oxidative damage, and increases extracellular signal-regulated kinase signaling in the heart of C57BL/6 mice.
Sanchez-Roman I, Gomez J, Naudi A, Ayala V, Portero-Otín M, Lopez-Torres M, Pamplona R, Barja G. Sanchez-Roman I, et al. Rejuvenation Res. 2010 Dec;13(6):683-93. doi: 10.1089/rej.2010.1062. Epub 2010 Sep 6. Rejuvenation Res. 2010. PMID: 20818929
[Calorie restriction, oxidative stress and longevity].
López-Torres M, Barja G. López-Torres M, et al. Rev Esp Geriatr Gerontol. 2008 Jul-Aug;43(4):252-60. doi: 10.1016/s0211-139x(08)71190-9. Rev Esp Geriatr Gerontol. 2008. PMID: 18682147 Free article. Review. Spanish.
Lifelong treatment with atenolol decreases membrane fatty acid unsaturation and oxidative stress in heart and skeletal muscle mitochondria and improves immunity and behavior, without changing mice longevity.
Gómez A, Sánchez-Roman I, Gomez J, Cruces J, Mate I, Lopez-Torres M, Naudi A, Portero-Otin M, Pamplona R, De la Fuente M, Barja G. Gómez A, et al. Aging Cell. 2014 Jun;13(3):551-60. doi: 10.1111/acel.12205. Epub 2014 Feb 26. Aging Cell. 2014. PMID: 24612513 Free PMC article.
92 results