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Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family.
Hewitson KS, McNeill LA, Riordan MV, Tian YM, Bullock AN, Welford RW, Elkins JM, Oldham NJ, Bhattacharya S, Gleadle JM, Ratcliffe PJ, Pugh CW, Schofield CJ. Hewitson KS, et al. Among authors: mcneill la. J Biol Chem. 2002 Jul 19;277(29):26351-5. doi: 10.1074/jbc.C200273200. Epub 2002 May 31. J Biol Chem. 2002. PMID: 12042299 Free article.
The selectivity and inhibition of AlkB.
Welford RW, Schlemminger I, McNeill LA, Hewitson KS, Schofield CJ. Welford RW, et al. Among authors: mcneill la. J Biol Chem. 2003 Mar 21;278(12):10157-61. doi: 10.1074/jbc.M211058200. Epub 2003 Jan 6. J Biol Chem. 2003. PMID: 12517755 Free article.
Analogues of dealanylalahopcin are inhibitors of human HIF prolyl hydroxylases.
Schlemminger I, Mole DR, McNeill LA, Dhanda A, Hewitson KS, Tian YM, Ratcliffe PJ, Pugh CW, Schofield CJ. Schlemminger I, et al. Among authors: mcneill la. Bioorg Med Chem Lett. 2003 Apr 17;13(8):1451-4. doi: 10.1016/s0960-894x(03)00149-5. Bioorg Med Chem Lett. 2003. PMID: 12668010
2-oxoglutarate analogue inhibitors of HIF prolyl hydroxylase.
Mole DR, Schlemminger I, McNeill LA, Hewitson KS, Pugh CW, Ratcliffe PJ, Schofield CJ. Mole DR, et al. Among authors: mcneill la. Bioorg Med Chem Lett. 2003 Aug 18;13(16):2677-80. doi: 10.1016/s0960-894x(03)00539-0. Bioorg Med Chem Lett. 2003. PMID: 12873492
Selective inhibition of factor inhibiting hypoxia-inducible factor.
McDonough MA, McNeill LA, Tilliet M, Papamicaël CA, Chen QY, Banerji B, Hewitson KS, Schofield CJ. McDonough MA, et al. Among authors: mcneill la. J Am Chem Soc. 2005 Jun 1;127(21):7680-1. doi: 10.1021/ja050841b. J Am Chem Soc. 2005. PMID: 15913349
Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2).
McDonough MA, Li V, Flashman E, Chowdhury R, Mohr C, Liénard BM, Zondlo J, Oldham NJ, Clifton IJ, Lewis J, McNeill LA, Kurzeja RJ, Hewitson KS, Yang E, Jordan S, Syed RS, Schofield CJ. McDonough MA, et al. Among authors: mcneill la. Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):9814-9. doi: 10.1073/pnas.0601283103. Epub 2006 Jun 16. Proc Natl Acad Sci U S A. 2006. PMID: 16782814 Free PMC article.
31 results