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Interleukin 15-mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1.
Huntington ND, Puthalakath H, Gunn P, Naik E, Michalak EM, Smyth MJ, Tabarias H, Degli-Esposti MA, Dewson G, Willis SN, Motoyama N, Huang DC, Nutt SL, Tarlinton DM, Strasser A. Huntington ND, et al. Among authors: dewson g. Nat Immunol. 2007 Aug;8(8):856-63. doi: 10.1038/ni1487. Epub 2007 Jul 8. Nat Immunol. 2007. PMID: 17618288 Free PMC article.
Fas-mediated neutrophil apoptosis is accelerated by Bid, Bak, and Bax and inhibited by Bcl-2 and Mcl-1.
Croker BA, O'Donnell JA, Nowell CJ, Metcalf D, Dewson G, Campbell KJ, Rogers KL, Hu Y, Smyth GK, Zhang JG, White M, Lackovic K, Cengia LH, O'Reilly LA, Bouillet P, Cory S, Strasser A, Roberts AW. Croker BA, et al. Among authors: dewson g. Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13135-40. doi: 10.1073/pnas.1110358108. Epub 2011 Jul 18. Proc Natl Acad Sci U S A. 2011. PMID: 21768356 Free PMC article.
BCL-2: Long and winding path from discovery to therapeutic target.
Schenk RL, Strasser A, Dewson G. Schenk RL, et al. Among authors: dewson g. Biochem Biophys Res Commun. 2017 Jan 15;482(3):459-469. doi: 10.1016/j.bbrc.2016.10.100. Epub 2017 Feb 3. Biochem Biophys Res Commun. 2017. PMID: 28212732 Review.
Synergistic action of the MCL-1 inhibitor S63845 with current therapies in preclinical models of triple-negative and HER2-amplified breast cancer.
Merino D, Whittle JR, Vaillant F, Serrano A, Gong JN, Giner G, Maragno AL, Chanrion M, Schneider E, Pal B, Li X, Dewson G, Gräsel J, Liu K, Lalaoui N, Segal D, Herold MJ, Huang DCS, Smyth GK, Geneste O, Lessene G, Visvader JE, Lindeman GJ. Merino D, et al. Among authors: dewson g. Sci Transl Med. 2017 Aug 2;9(401):eaam7049. doi: 10.1126/scitranslmed.aam7049. Sci Transl Med. 2017. PMID: 28768804
A critical epithelial survival axis regulated by MCL-1 maintains thymic function in mice.
Jain R, Sheridan JM, Policheni A, Heinlein M, Gandolfo LC, Dewson G, Smyth GK, Sansom SN, Fu NY, Visvader JE, Holländer GA, Strasser A, Gray DHD. Jain R, et al. Among authors: dewson g. Blood. 2017 Dec 7;130(23):2504-2515. doi: 10.1182/blood-2017-03-771576. Epub 2017 Sep 29. Blood. 2017. PMID: 28972012 Free PMC article.
How do thymic epithelial cells die?
Jain R, Mintern JD, Tan I, Dewson G, Strasser A, Gray DHD. Jain R, et al. Among authors: dewson g. Cell Death Differ. 2018 May;25(5):1002-1004. doi: 10.1038/s41418-018-0093-8. Epub 2018 Mar 16. Cell Death Differ. 2018. PMID: 29549302 Free PMC article. No abstract available.
91 results