Michalak EM - Search Results

1

Maximal killing of lymphoma cells by DNA damage-inducing therapy requires not only the p53 targets Puma and Noxa, but also Bim.

Happo L, Cragg MS, Phipson B, Haga JM, Jansen ES, Herold MJ, Dewson G, Michalak EM, Vandenberg CJ, Smyth GK, Strasser A, Cory S, Scott CL. Happo L, et al. Among authors: michalak em. Blood. 2010 Dec 9;116(24):5256-67. doi: 10.1182/blood-2010-04-280818. Epub 2010 Sep 9. Blood. 2010. PMID: 20829369 Free PMC article.

2

In several cell types tumour suppressor p53 induces apoptosis largely via Puma but Noxa can contribute.

Michalak EM, Villunger A, Adams JM, Strasser A. Michalak EM, et al. Cell Death Differ. 2008 Jun;15(6):1019-29. doi: 10.1038/cdd.2008.16. Epub 2008 Feb 8. Cell Death Differ. 2008. PMID: 18259198 Free PMC article.

3

Puma and to a lesser extent Noxa are suppressors of Myc-induced lymphomagenesis.

Michalak EM, Jansen ES, Happo L, Cragg MS, Tai L, Smyth GK, Strasser A, Adams JM, Scott CL. Michalak EM, et al. Cell Death Differ. 2009 May;16(5):684-96. doi: 10.1038/cdd.2008.195. Epub 2009 Jan 16. Cell Death Differ. 2009. PMID: 19148184 Free PMC article.

4

Apoptosis-promoted tumorigenesis: gamma-irradiation-induced thymic lymphomagenesis requires Puma-driven leukocyte death.

Michalak EM, Vandenberg CJ, Delbridge AR, Wu L, Scott CL, Adams JM, Strasser A. Michalak EM, et al. Genes Dev. 2010 Aug 1;24(15):1608-13. doi: 10.1101/gad.1940110. Genes Dev. 2010. PMID: 20679396 Free PMC article.

5

p53 efficiently suppresses tumor development in the complete absence of its cell-cycle inhibitory and proapoptotic effectors p21, Puma, and Noxa.

Valente LJ, Gray DH, Michalak EM, Pinon-Hofbauer J, Egle A, Scott CL, Janic A, Strasser A. Valente LJ, et al. Among authors: michalak em. Cell Rep. 2013 May 30;3(5):1339-45. doi: 10.1016/j.celrep.2013.04.012. Epub 2013 May 9. Cell Rep. 2013. PMID: 23665218 Free article.

6

DNA damage-induced primordial follicle oocyte apoptosis and loss of fertility require TAp63-mediated induction of Puma and Noxa.

Kerr JB, Hutt KJ, Michalak EM, Cook M, Vandenberg CJ, Liew SH, Bouillet P, Mills A, Scott CL, Findlay JK, Strasser A. Kerr JB, et al. Among authors: michalak em. Mol Cell. 2012 Nov 9;48(3):343-52. doi: 10.1016/j.molcel.2012.08.017. Epub 2012 Sep 20. Mol Cell. 2012. PMID: 23000175 Free PMC article.

7

Death squads enlisted by the tumour suppressor p53.

Michalak E, Villunger A, Erlacher M, Strasser A. Michalak E, et al. Biochem Biophys Res Commun. 2005 Jun 10;331(3):786-98. doi: 10.1016/j.bbrc.2005.03.183. Biochem Biophys Res Commun. 2005. PMID: 15865934 Review.

8

p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa.

Villunger A, Michalak EM, Coultas L, Müllauer F, Böck G, Ausserlechner MJ, Adams JM, Strasser A. Villunger A, et al. Among authors: michalak em. Science. 2003 Nov 7;302(5647):1036-8. doi: 10.1126/science.1090072. Epub 2003 Sep 18. Science. 2003. PMID: 14500851

9

BH3-only proteins Puma and Bim are rate-limiting for gamma-radiation- and glucocorticoid-induced apoptosis of lymphoid cells in vivo.

Erlacher M, Michalak EM, Kelly PN, Labi V, Niederegger H, Coultas L, Adams JM, Strasser A, Villunger A. Erlacher M, et al. Among authors: michalak em. Blood. 2005 Dec 15;106(13):4131-8. doi: 10.1182/blood-2005-04-1595. Epub 2005 Aug 23. Blood. 2005. PMID: 16118324 Free PMC article.

10

Cell death provoked by loss of interleukin-3 signaling is independent of Bad, Bim, and PI3 kinase, but depends in part on Puma.

Ekert PG, Jabbour AM, Manoharan A, Heraud JE, Yu J, Pakusch M, Michalak EM, Kelly PN, Callus B, Kiefer T, Verhagen A, Silke J, Strasser A, Borner C, Vaux DL. Ekert PG, et al. Among authors: michalak em. Blood. 2006 Sep 1;108(5):1461-8. doi: 10.1182/blood-2006-03-014209. Epub 2006 May 16. Blood. 2006. PMID: 16705087 Free article.

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