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TCF7L2 is a master regulator of insulin production and processing.
Zhou Y, Park SY, Su J, Bailey K, Ottosson-Laakso E, Shcherbina L, Oskolkov N, Zhang E, Thevenin T, Fadista J, Bennet H, Vikman P, Wierup N, Fex M, Rung J, Wollheim C, Nobrega M, Renström E, Groop L, Hansson O. Zhou Y, et al. Hum Mol Genet. 2014 Dec 15;23(24):6419-31. doi: 10.1093/hmg/ddu359. Epub 2014 Jul 11. Hum Mol Genet. 2014. PMID: 25015099 Free PMC article.
HMGB1 binds to the rs7903146 locus in TCF7L2 in human pancreatic islets.
Zhou Y, Oskolkov N, Shcherbina L, Ratti J, Kock KH, Su J, Martin B, Oskolkova MZ, Göransson O, Bacon J, Li W, Bucciarelli S, Cilio C, Brazma A, Thatcher B, Rung J, Wierup N, Renström E, Groop L, Hansson O. Zhou Y, et al. Mol Cell Endocrinol. 2016 Jul 15;430:138-45. doi: 10.1016/j.mce.2016.01.027. Epub 2016 Feb 1. Mol Cell Endocrinol. 2016. PMID: 26845344
A systems genetics approach identifies genes and pathways for type 2 diabetes in human islets.
Taneera J, Lang S, Sharma A, Fadista J, Zhou Y, Ahlqvist E, Jonsson A, Lyssenko V, Vikman P, Hansson O, Parikh H, Korsgren O, Soni A, Krus U, Zhang E, Jing XJ, Esguerra JL, Wollheim CB, Salehi A, Rosengren A, Renström E, Groop L. Taneera J, et al. Among authors: zhou y. Cell Metab. 2012 Jul 3;16(1):122-34. doi: 10.1016/j.cmet.2012.06.006. Cell Metab. 2012. PMID: 22768844 Free article.
Secreted frizzled-related protein 4 reduces insulin secretion and is overexpressed in type 2 diabetes.
Mahdi T, Hänzelmann S, Salehi A, Muhammed SJ, Reinbothe TM, Tang Y, Axelsson AS, Zhou Y, Jing X, Almgren P, Krus U, Taneera J, Blom AM, Lyssenko V, Esguerra JL, Hansson O, Eliasson L, Derry J, Zhang E, Wollheim CB, Groop L, Renström E, Rosengren AH. Mahdi T, et al. Among authors: zhou y. Cell Metab. 2012 Nov 7;16(5):625-33. doi: 10.1016/j.cmet.2012.10.009. Cell Metab. 2012. PMID: 23140642 Free article.
A common variant upstream of the PAX6 gene influences islet function in man.
Ahlqvist E, Turrini F, Lang ST, Taneera J, Zhou Y, Almgren P, Hansson O, Isomaa B, Tuomi T, Eriksson K, Eriksson JG, Lyssenko V, Groop L. Ahlqvist E, et al. Among authors: zhou y. Diabetologia. 2012 Jan;55(1):94-104. doi: 10.1007/s00125-011-2300-8. Epub 2011 Sep 16. Diabetologia. 2012. PMID: 21922321
Excess maternal transmission of variants in the THADA gene to offspring with type 2 diabetes.
Prasad RB, Lessmark A, Almgren P, Kovacs G, Hansson O, Oskolkov N, Vitai M, Ladenvall C, Kovacs P, Fadista J, Lachmann M, Zhou Y, Sonestedt E, Poon W, Wollheim CB, Orho-Melander M, Stumvoll M, Tuomi T, Pääbo S, Koranyi L, Groop L. Prasad RB, et al. Among authors: zhou y. Diabetologia. 2016 Aug;59(8):1702-13. doi: 10.1007/s00125-016-3973-9. Epub 2016 May 7. Diabetologia. 2016. PMID: 27155871
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