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A novel mouse model of cerebral cavernous malformations based on the two-hit mutation hypothesis recapitulates the human disease.
McDonald DA, Shenkar R, Shi C, Stockton RA, Akers AL, Kucherlapati MH, Kucherlapati R, Brainer J, Ginsberg MH, Awad IA, Marchuk DA. McDonald DA, et al. Among authors: kucherlapati r, kucherlapati mh. Hum Mol Genet. 2011 Jan 15;20(2):211-22. doi: 10.1093/hmg/ddq433. Epub 2010 Oct 11. Hum Mol Genet. 2011. PMID: 20940147 Free PMC article.
An Msh2 conditional knockout mouse for studying intestinal cancer and testing anticancer agents.
Kucherlapati MH, Lee K, Nguyen AA, Clark AB, Hou H Jr, Rosulek A, Li H, Yang K, Fan K, Lipkin M, Bronson RT, Jelicks L, Kunkel TA, Kucherlapati R, Edelmann W. Kucherlapati MH, et al. Among authors: kucherlapati r. Gastroenterology. 2010 Mar;138(3):993-1002.e1. doi: 10.1053/j.gastro.2009.11.009. Epub 2009 Nov 18. Gastroenterology. 2010. PMID: 19931261 Free PMC article.
Genotype directed therapy in murine mismatch repair deficient tumors.
Kucherlapati MH, Esfahani S, Habibollahi P, Wang J, Still ER, Bronson RT, Mahmood U, Kucherlapati RS. Kucherlapati MH, et al. Among authors: kucherlapati rs. PLoS One. 2013 Jul 23;8(7):e68817. doi: 10.1371/journal.pone.0068817. Print 2013. PLoS One. 2013. PMID: 23935891 Free PMC article.
Aspirin and low-dose nitric oxide-donating aspirin increase life span in a Lynch syndrome mouse model.
McIlhatton MA, Tyler J, Kerepesi LA, Bocker-Edmonston T, Kucherlapati MH, Edelmann W, Kucherlapati R, Kopelovich L, Fishel R. McIlhatton MA, et al. Among authors: kucherlapati r, kucherlapati mh. Cancer Prev Res (Phila). 2011 May;4(5):684-93. doi: 10.1158/1940-6207.CAPR-10-0319. Epub 2011 Mar 24. Cancer Prev Res (Phila). 2011. PMID: 21436383 Free PMC article.
Tumor progression in Apc(1638N) mice with Exo1 and Fen1 deficiencies.
Kucherlapati M, Nguyen A, Kuraguchi M, Yang K, Fan K, Bronson R, Wei K, Lipkin M, Edelmann W, Kucherlapati R. Kucherlapati M, et al. Oncogene. 2007 Sep 20;26(43):6297-306. doi: 10.1038/sj.onc.1210453. Epub 2007 Apr 23. Oncogene. 2007. PMID: 17452984
Haploinsufficiency of Flap endonuclease (Fen1) leads to rapid tumor progression.
Kucherlapati M, Yang K, Kuraguchi M, Zhao J, Lia M, Heyer J, Kane MF, Fan K, Russell R, Brown AM, Kneitz B, Edelmann W, Kolodner RD, Lipkin M, Kucherlapati R. Kucherlapati M, et al. Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):9924-9. doi: 10.1073/pnas.152321699. Epub 2002 Jul 15. Proc Natl Acad Sci U S A. 2002. PMID: 12119409 Free PMC article.
60 results