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A novel mouse model of cerebral cavernous malformations based on the two-hit mutation hypothesis recapitulates the human disease.
McDonald DA, Shenkar R, Shi C, Stockton RA, Akers AL, Kucherlapati MH, Kucherlapati R, Brainer J, Ginsberg MH, Awad IA, Marchuk DA. McDonald DA, et al. Among authors: kucherlapati r, kucherlapati mh. Hum Mol Genet. 2011 Jan 15;20(2):211-22. doi: 10.1093/hmg/ddq433. Epub 2010 Oct 11. Hum Mol Genet. 2011. PMID: 20940147 Free PMC article.
An Msh2 conditional knockout mouse for studying intestinal cancer and testing anticancer agents.
Kucherlapati MH, Lee K, Nguyen AA, Clark AB, Hou H Jr, Rosulek A, Li H, Yang K, Fan K, Lipkin M, Bronson RT, Jelicks L, Kunkel TA, Kucherlapati R, Edelmann W. Kucherlapati MH, et al. Among authors: kucherlapati r. Gastroenterology. 2010 Mar;138(3):993-1002.e1. doi: 10.1053/j.gastro.2009.11.009. Epub 2009 Nov 18. Gastroenterology. 2010. PMID: 19931261 Free PMC article.
Aspirin and low-dose nitric oxide-donating aspirin increase life span in a Lynch syndrome mouse model.
McIlhatton MA, Tyler J, Kerepesi LA, Bocker-Edmonston T, Kucherlapati MH, Edelmann W, Kucherlapati R, Kopelovich L, Fishel R. McIlhatton MA, et al. Among authors: kucherlapati r, kucherlapati mh. Cancer Prev Res (Phila). 2011 May;4(5):684-93. doi: 10.1158/1940-6207.CAPR-10-0319. Epub 2011 Mar 24. Cancer Prev Res (Phila). 2011. PMID: 21436383 Free PMC article.
Adenomatous polyposis coli (APC) is required for normal development of skin and thymus.
Kuraguchi M, Wang XP, Bronson RT, Rothenberg R, Ohene-Baah NY, Lund JJ, Kucherlapati M, Maas RL, Kucherlapati R. Kuraguchi M, et al. Among authors: kucherlapati r, kucherlapati m. PLoS Genet. 2006 Sep 15;2(9):e146. doi: 10.1371/journal.pgen.0020146. Epub 2006 Jul 28. PLoS Genet. 2006. PMID: 17002498 Free PMC article.
Msh2 acts in medium-spiny striatal neurons as an enhancer of CAG instability and mutant huntingtin phenotypes in Huntington's disease knock-in mice.
Kovalenko M, Dragileva E, St Claire J, Gillis T, Guide JR, New J, Dong H, Kucherlapati R, Kucherlapati MH, Ehrlich ME, Lee JM, Wheeler VC. Kovalenko M, et al. Among authors: kucherlapati r, kucherlapati mh. PLoS One. 2012;7(9):e44273. doi: 10.1371/journal.pone.0044273. Epub 2012 Sep 7. PLoS One. 2012. PMID: 22970194 Free PMC article.
Tumor progression in Apc(1638N) mice with Exo1 and Fen1 deficiencies.
Kucherlapati M, Nguyen A, Kuraguchi M, Yang K, Fan K, Bronson R, Wei K, Lipkin M, Edelmann W, Kucherlapati R. Kucherlapati M, et al. Among authors: kucherlapati r. Oncogene. 2007 Sep 20;26(43):6297-306. doi: 10.1038/sj.onc.1210453. Epub 2007 Apr 23. Oncogene. 2007. PMID: 17452984
Haploinsufficiency of Flap endonuclease (Fen1) leads to rapid tumor progression.
Kucherlapati M, Yang K, Kuraguchi M, Zhao J, Lia M, Heyer J, Kane MF, Fan K, Russell R, Brown AM, Kneitz B, Edelmann W, Kolodner RD, Lipkin M, Kucherlapati R. Kucherlapati M, et al. Among authors: kucherlapati r. Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):9924-9. doi: 10.1073/pnas.152321699. Epub 2002 Jul 15. Proc Natl Acad Sci U S A. 2002. PMID: 12119409 Free PMC article.
394 results