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Synthetic lethality screens reveal RPS6 and MST1R as modifiers of insulin-like growth factor-1 receptor inhibitor activity in childhood sarcomas.
Potratz JC, Saunders DN, Wai DH, Ng TL, McKinney SE, Carboni JM, Gottardis MM, Triche TJ, Jürgens H, Pollak MN, Aparicio SA, Sorensen PH. Potratz JC, et al. Among authors: saunders dn. Cancer Res. 2010 Nov 1;70(21):8770-81. doi: 10.1158/0008-5472.CAN-10-1093. Epub 2010 Oct 19. Cancer Res. 2010. PMID: 20959493
CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours.
Xu H, Di Antonio M, McKinney S, Mathew V, Ho B, O'Neil NJ, Santos ND, Silvester J, Wei V, Garcia J, Kabeer F, Lai D, Soriano P, Banáth J, Chiu DS, Yap D, Le DD, Ye FB, Zhang A, Thu K, Soong J, Lin SC, Tsai AH, Osako T, Algara T, Saunders DN, Wong J, Xian J, Bally MB, Brenton JD, Brown GW, Shah SP, Cescon D, Mak TW, Caldas C, Stirling PC, Hieter P, Balasubramanian S, Aparicio S. Xu H, et al. Among authors: saunders dn. Nat Commun. 2017 Feb 17;8:14432. doi: 10.1038/ncomms14432. Nat Commun. 2017. PMID: 28211448 Free PMC article.
Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer.
Kennedy SP, Han JZR, Portman N, Nobis M, Hastings JF, Murphy KJ, Latham SL, Cadell AL, Miladinovic D, Marriott GR, O'Donnell YEI, Shearer RF, Williams JT, Munoz AG, Cox TR, Watkins DN, Saunders DN, Timpson P, Lim E, Kolch W, Croucher DR. Kennedy SP, et al. Among authors: saunders dn. Breast Cancer Res. 2019 Mar 21;21(1):43. doi: 10.1186/s13058-019-1127-y. Breast Cancer Res. 2019. PMID: 30898150 Free PMC article.
Functional Roles of the E3 Ubiquitin Ligase UBR5 in Cancer.
Shearer RF, Iconomou M, Watts CK, Saunders DN. Shearer RF, et al. Among authors: saunders dn. Mol Cancer Res. 2015 Dec;13(12):1523-32. doi: 10.1158/1541-7786.MCR-15-0383. Epub 2015 Oct 13. Mol Cancer Res. 2015. PMID: 26464214 Review.
Membranous expression of secreted frizzled-related protein 4 predicts for good prognosis in localized prostate cancer and inhibits PC3 cellular proliferation in vitro.
Horvath LG, Henshall SM, Kench JG, Saunders DN, Lee CS, Golovsky D, Brenner PC, O'Neill GF, Kooner R, Stricker PD, Grygiel JJ, Sutherland RL. Horvath LG, et al. Among authors: saunders dn. Clin Cancer Res. 2004 Jan 15;10(2):615-25. doi: 10.1158/1078-0432.ccr-0707-03. Clin Cancer Res. 2004. PMID: 14760084
Extracellular Fatty Acids Are the Major Contributor to Lipid Synthesis in Prostate Cancer.
Balaban S, Nassar ZD, Zhang AY, Hosseini-Beheshti E, Centenera MM, Schreuder M, Lin HM, Aishah A, Varney B, Liu-Fu F, Lee LS, Nagarajan SR, Shearer RF, Hardie RA, Raftopulos NL, Kakani MS, Saunders DN, Holst J, Horvath LG, Butler LM, Hoy AJ. Balaban S, et al. Among authors: saunders dn. Mol Cancer Res. 2019 Apr;17(4):949-962. doi: 10.1158/1541-7786.MCR-18-0347. Epub 2019 Jan 15. Mol Cancer Res. 2019. PMID: 30647103
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