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331 results

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Specific variants in the MLH1 gene region may drive DNA methylation, loss of protein expression, and MSI-H colorectal cancer.
Mrkonjic M, Roslin NM, Greenwood CM, Raptis S, Pollett A, Laird PW, Pethe VV, Chiang T, Daftary D, Dicks E, Thibodeau SN, Gallinger S, Parfrey PS, Younghusband HB, Potter JD, Hudson TJ, McLaughlin JR, Green RC, Zanke BW, Newcomb PA, Paterson AD, Bapat B. Mrkonjic M, et al. Among authors: laird pw. PLoS One. 2010 Oct 13;5(10):e13314. doi: 10.1371/journal.pone.0013314. PLoS One. 2010. PMID: 20967208 Free PMC article.
CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer.
Weisenberger DJ, Siegmund KD, Campan M, Young J, Long TI, Faasse MA, Kang GH, Widschwendter M, Weener D, Buchanan D, Koh H, Simms L, Barker M, Leggett B, Levine J, Kim M, French AJ, Thibodeau SN, Jass J, Haile R, Laird PW. Weisenberger DJ, et al. Among authors: laird pw. Nat Genet. 2006 Jul;38(7):787-93. doi: 10.1038/ng1834. Epub 2006 Jun 25. Nat Genet. 2006. PMID: 16804544
Molecular characterization of MSI-H colorectal cancer by MLHI promoter methylation, immunohistochemistry, and mismatch repair germline mutation screening.
Poynter JN, Siegmund KD, Weisenberger DJ, Long TI, Thibodeau SN, Lindor N, Young J, Jenkins MA, Hopper JL, Baron JA, Buchanan D, Casey G, Levine AJ, Le Marchand L, Gallinger S, Bapat B, Potter JD, Newcomb PA, Haile RW, Laird PW; Colon Cancer Family Registry Investigators. Poynter JN, et al. Among authors: laird pw. Cancer Epidemiol Biomarkers Prev. 2008 Nov;17(11):3208-15. doi: 10.1158/1055-9965.EPI-08-0512. Cancer Epidemiol Biomarkers Prev. 2008. PMID: 18990764 Free PMC article.
Epigenomics-based diagnostics.
Diamandis EP, Sidransky D, Laird PW, Cairns P, Bapat B. Diamandis EP, et al. Among authors: laird pw. Clin Chem. 2010 Aug;56(8):1216-9. doi: 10.1373/clinchem.2010.148007. Epub 2010 May 14. Clin Chem. 2010. PMID: 20472819 No abstract available.
Cigarette smoking and colorectal cancer risk by molecularly defined subtypes.
Limsui D, Vierkant RA, Tillmans LS, Wang AH, Weisenberger DJ, Laird PW, Lynch CF, Anderson KE, French AJ, Haile RW, Harnack LJ, Potter JD, Slager SL, Smyrk TC, Thibodeau SN, Cerhan JR, Limburg PJ. Limsui D, et al. Among authors: laird pw. J Natl Cancer Inst. 2010 Jul 21;102(14):1012-22. doi: 10.1093/jnci/djq201. Epub 2010 Jun 29. J Natl Cancer Inst. 2010. PMID: 20587792 Free PMC article.
Frequency of deletions of EPCAM (TACSTD1) in MSH2-associated Lynch syndrome cases.
Rumilla K, Schowalter KV, Lindor NM, Thomas BC, Mensink KA, Gallinger S, Holter S, Newcomb PA, Potter JD, Jenkins MA, Hopper JL, Long TI, Weisenberger DJ, Haile RW, Casey G, Laird PW, Le Marchand L, Thibodeau SN. Rumilla K, et al. Among authors: laird pw. J Mol Diagn. 2011 Jan;13(1):93-9. doi: 10.1016/j.jmoldx.2010.11.011. Epub 2010 Dec 23. J Mol Diagn. 2011. PMID: 21227399 Free PMC article.
Alcohol intake and colorectal cancer risk by molecularly defined subtypes in a prospective study of older women.
Razzak AA, Oxentenko AS, Vierkant RA, Tillmans LS, Wang AH, Weisenberger DJ, Laird PW, Lynch CF, Anderson KE, French AJ, Haile RW, Harnack LJ, Slager SL, Smyrk TC, Thibodeau SN, Cerhan JR, Limburg PJ. Razzak AA, et al. Among authors: laird pw. Cancer Prev Res (Phila). 2011 Dec;4(12):2035-43. doi: 10.1158/1940-6207.CAPR-11-0276. Epub 2011 Sep 7. Cancer Prev Res (Phila). 2011. PMID: 21900595 Free PMC article. Clinical Trial.
Postmenopausal hormone therapy and colorectal cancer risk by molecularly defined subtypes among older women.
Limsui D, Vierkant RA, Tillmans LS, Wang AH, Weisenberger DJ, Laird PW, Lynch CF, Anderson KE, French AJ, Haile RW, Harnack LJ, Potter JD, Slager SL, Smyrk TC, Thibodeau SN, Cerhan JR, Limburg PJ. Limsui D, et al. Among authors: laird pw. Gut. 2012 Sep;61(9):1299-305. doi: 10.1136/gutjnl-2011-300719. Epub 2011 Oct 24. Gut. 2012. PMID: 22027477 Free PMC article.
Cancer risks for the relatives of colorectal cancer cases with a methylated MLH1 promoter region: data from the Colorectal Cancer Family Registry.
Levine AJ, Win AK, Buchanan DD, Jenkins MA, Baron JA, Young JP, Long TI, Weisenberger DJ, Laird PW, McCall RL, Duggan DJ, Haile RW. Levine AJ, et al. Among authors: laird pw. Cancer Prev Res (Phila). 2012 Feb;5(2):328-35. doi: 10.1158/1940-6207.CAPR-11-0419. Epub 2011 Dec 5. Cancer Prev Res (Phila). 2012. PMID: 22144422 Free PMC article.
Associations between intake of folate and related micronutrients with molecularly defined colorectal cancer risks in the Iowa Women's Health Study.
Razzak AA, Oxentenko AS, Vierkant RA, Tillmans LS, Wang AH, Weisenberger DJ, Laird PW, Lynch CF, Anderson KE, French AJ, Haile RW, Harnack LJ, Potter JD, Slager SL, Smyrk TC, Thibodeau SN, Cerhan JR, Limburg PJ. Razzak AA, et al. Among authors: laird pw. Nutr Cancer. 2012;64(7):899-910. doi: 10.1080/01635581.2012.714833. Nutr Cancer. 2012. PMID: 23061900 Free PMC article.
331 results