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Specific variants in the MLH1 gene region may drive DNA methylation, loss of protein expression, and MSI-H colorectal cancer.
Mrkonjic M, Roslin NM, Greenwood CM, Raptis S, Pollett A, Laird PW, Pethe VV, Chiang T, Daftary D, Dicks E, Thibodeau SN, Gallinger S, Parfrey PS, Younghusband HB, Potter JD, Hudson TJ, McLaughlin JR, Green RC, Zanke BW, Newcomb PA, Paterson AD, Bapat B. Mrkonjic M, et al. PLoS One. 2010 Oct 13;5(10):e13314. doi: 10.1371/journal.pone.0013314. PLoS One. 2010. PMID: 20967208 Free PMC article.
The genetic basis of colorectal cancer in a population-based incident cohort with a high rate of familial disease.
Woods MO, Younghusband HB, Parfrey PS, Gallinger S, McLaughlin J, Dicks E, Stuckless S, Pollett A, Bapat B, Mrkonjic M, de la Chapelle A, Clendenning M, Thibodeau SN, Simms M, Dohey A, Williams P, Robb D, Searle C, Green JS, Green RC. Woods MO, et al. Among authors: mrkonjic m. Gut. 2010 Oct;59(10):1369-77. doi: 10.1136/gut.2010.208462. Epub 2010 Aug 3. Gut. 2010. PMID: 20682701 Free PMC article.
Promoter methylation of Wnt antagonists DKK1 and SFRP1 is associated with opposing tumor subtypes in two large populations of colorectal cancer patients.
Rawson JB, Manno M, Mrkonjic M, Daftary D, Dicks E, Buchanan DD, Younghusband HB, Parfrey PS, Young JP, Pollett A, Green RC, Gallinger S, McLaughlin JR, Knight JA, Bapat B. Rawson JB, et al. Among authors: mrkonjic m. Carcinogenesis. 2011 May;32(5):741-7. doi: 10.1093/carcin/bgr020. Epub 2011 Feb 8. Carcinogenesis. 2011. PMID: 21304055 Free PMC article.
Promoter methylation of Wnt5a is associated with microsatellite instability and BRAF V600E mutation in two large populations of colorectal cancer patients.
Rawson JB, Mrkonjic M, Daftary D, Dicks E, Buchanan DD, Younghusband HB, Parfrey PS, Young JP, Pollett A, Green RC, Gallinger S, McLaughlin JR, Knight JA, Bapat B. Rawson JB, et al. Among authors: mrkonjic m. Br J Cancer. 2011 Jun 7;104(12):1906-12. doi: 10.1038/bjc.2011.165. Epub 2011 May 17. Br J Cancer. 2011. PMID: 21587258 Free PMC article.
19 results