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Specific variants in the MLH1 gene region may drive DNA methylation, loss of protein expression, and MSI-H colorectal cancer.
Mrkonjic M, Roslin NM, Greenwood CM, Raptis S, Pollett A, Laird PW, Pethe VV, Chiang T, Daftary D, Dicks E, Thibodeau SN, Gallinger S, Parfrey PS, Younghusband HB, Potter JD, Hudson TJ, McLaughlin JR, Green RC, Zanke BW, Newcomb PA, Paterson AD, Bapat B. Mrkonjic M, et al. Among authors: pethe vv. PLoS One. 2010 Oct 13;5(10):e13314. doi: 10.1371/journal.pone.0013314. PLoS One. 2010. PMID: 20967208 Free PMC article.
MYH mutations are rare in prostate cancer.
Shin EJ, Chappell E, Pethe V, Hersey K, van der Kwast T, Fleshner N, Bapat B. Shin EJ, et al. J Cancer Res Clin Oncol. 2007 Jun;133(6):373-8. doi: 10.1007/s00432-006-0181-x. Epub 2007 Jan 12. J Cancer Res Clin Oncol. 2007. PMID: 17219200
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