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Identification of low molecular weight pyroglutamate A{beta} oligomers in Alzheimer disease: a novel tool for therapy and diagnosis.
Wirths O, Erck C, Martens H, Harmeier A, Geumann C, Jawhar S, Kumar S, Multhaup G, Walter J, Ingelsson M, Degerman-Gunnarsson M, Kalimo H, Huitinga I, Lannfelt L, Bayer TA. Wirths O, et al. Among authors: kumar s. J Biol Chem. 2010 Dec 31;285(53):41517-24. doi: 10.1074/jbc.M110.178707. Epub 2010 Oct 22. J Biol Chem. 2010. PMID: 20971852 Free PMC article.
Statins promote the degradation of extracellular amyloid {beta}-peptide by microglia via stimulation of exosome-associated insulin-degrading enzyme (IDE) secretion.
Tamboli IY, Barth E, Christian L, Siepmann M, Kumar S, Singh S, Tolksdorf K, Heneka MT, Lütjohann D, Wunderlich P, Walter J. Tamboli IY, et al. Among authors: kumar s. J Biol Chem. 2010 Nov 26;285(48):37405-14. doi: 10.1074/jbc.M110.149468. Epub 2010 Sep 28. J Biol Chem. 2010. PMID: 20876579 Free PMC article.
Dispersible amyloid β-protein oligomers, protofibrils, and fibrils represent diffusible but not soluble aggregates: their role in neurodegeneration in amyloid precursor protein (APP) transgenic mice.
Rijal Upadhaya A, Capetillo-Zarate E, Kosterin I, Abramowski D, Kumar S, Yamaguchi H, Walter J, Fändrich M, Staufenbiel M, Thal DR. Rijal Upadhaya A, et al. Among authors: kumar s. Neurobiol Aging. 2012 Nov;33(11):2641-60. doi: 10.1016/j.neurobiolaging.2011.12.032. Epub 2012 Feb 2. Neurobiol Aging. 2012. PMID: 22305478
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