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Extracellular loop C of NPC1L1 is important for binding to ezetimibe.
Weinglass AB, Kohler M, Schulte U, Liu J, Nketiah EO, Thomas A, Schmalhofer W, Williams B, Bildl W, McMasters DR, Dai K, Beers L, McCann ME, Kaczorowski GJ, Garcia ML. Weinglass AB, et al. Among authors: mcmasters dr. Proc Natl Acad Sci U S A. 2008 Aug 12;105(32):11140-5. doi: 10.1073/pnas.0800936105. Epub 2008 Aug 5. Proc Natl Acad Sci U S A. 2008. PMID: 18682566 Free PMC article.
Structure-based design of novel groups for use in the P1 position of thrombin inhibitor scaffolds. Part 2: N-acetamidoimidazoles.
Isaacs RC, Solinsky MG, Cutrona KJ, Newton CL, Naylor-Olsen AM, McMasters DR, Krueger JA, Lewis SD, Lucas BJ, Kuo LC, Yan Y, Lynch JJ, Lyle EA. Isaacs RC, et al. Among authors: mcmasters dr. Bioorg Med Chem Lett. 2008 Mar 15;18(6):2062-6. doi: 10.1016/j.bmcl.2008.01.098. Epub 2008 Jan 30. Bioorg Med Chem Lett. 2008. PMID: 18291642
Discovery of a novel class of isoxazoline voltage gated sodium channel blockers.
Shao PP, Ye F, Weber AE, Li X, Lyons KA, Parsons WH, Garcia ML, Priest BT, Smith MM, Felix JP, Williams BS, Kaczorowski GJ, McGowan E, Abbadie C, Martin WJ, McMasters DR, Gao YD. Shao PP, et al. Among authors: mcmasters dr. Bioorg Med Chem Lett. 2009 Sep 15;19(18):5329-33. doi: 10.1016/j.bmcl.2009.07.125. Epub 2009 Aug 6. Bioorg Med Chem Lett. 2009. PMID: 19674896
Discovery of potent, selective 4-fluoroproline-based thrombin inhibitors with improved metabolic stability.
Staas DD, Savage KL, Sherman VL, Shimp HL, Lyle TA, Tran LO, Wiscount CM, McMasters DR, Sanderson PE, Williams PD, Lucas BJ Jr, Krueger JA, Lewis SD, White RB, Yu S, Wong BK, Kochansky CJ, Anari MR, Yan Y, Vacca JP. Staas DD, et al. Among authors: mcmasters dr. Bioorg Med Chem. 2006 Oct 15;14(20):6900-16. doi: 10.1016/j.bmc.2006.06.040. Epub 2006 Jul 25. Bioorg Med Chem. 2006. PMID: 16870455
Design and synthesis of potent and selective macrocyclic thrombin inhibitors.
Nantermet PG, Barrow JC, Newton CL, Pellicore JM, Young M, Lewis SD, Lucas BJ, Krueger JA, McMasters DR, Yan Y, Kuo LC, Vacca JP, Selnick HG. Nantermet PG, et al. Among authors: mcmasters dr. Bioorg Med Chem Lett. 2003 Aug 18;13(16):2781-4. doi: 10.1016/s0960-894x(03)00506-7. Bioorg Med Chem Lett. 2003. PMID: 12873514
Design, synthesis and SAR of a series of 1,3,5-trisubstituted benzenes as thrombin inhibitors.
Isaacs RC, Newton CL, Cutrona KJ, Mercer SP, Payne LS, Stauffer KJ, Williams PD, Cook JJ, Krueger JA, Lewis SD, Lucas BJ, Lyle EA, Lynch JJ, McMasters DR, Naylor-Olsen AM, Michener MT, Wallace AA. Isaacs RC, et al. Among authors: mcmasters dr. Bioorg Med Chem Lett. 2011 Mar 1;21(5):1536-40. doi: 10.1016/j.bmcl.2010.12.105. Epub 2010 Dec 28. Bioorg Med Chem Lett. 2011. PMID: 21295467
49 results