Saavedra JE - Search Results

1

Dual mechanisms of HNO generation by a nitroxyl prodrug of the diazeniumdiolate (NONOate) class.

Andrei D, Salmon DJ, Donzelli S, Wahab A, Klose JR, Citro ML, Saavedra JE, Wink DA, Miranda KM, Keefer LK. Andrei D, et al. Among authors: saavedra je. J Am Chem Soc. 2010 Nov 24;132(46):16526-32. doi: 10.1021/ja106552p. Epub 2010 Oct 29. J Am Chem Soc. 2010. PMID: 21033665 Free PMC article.

2

Chemistry of the diazeniumdiolates. O- versus N-alkylation of the RNH[N(O)NO](-) ion.

Saavedra JE, Bohle DS, Smith KN, George C, Deschamps JR, Parrish D, Ivanic J, Wang YN, Citro ML, Keefer LK. Saavedra JE, et al. J Am Chem Soc. 2004 Oct 13;126(40):12880-7. doi: 10.1021/ja031538i. J Am Chem Soc. 2004. PMID: 15469285

3

Chemistry of the diazeniumdiolates: Z right harpoon over left harpoon E isomerism.

Wang YN, Bohle DS, Bonifant CL, Chmurny GN, Collins JR, Davies KM, Deschamps J, Flippen-Anderson JL, Keefer LK, Klose JR, Saavedra JE, Waterhouse DJ, Ivanic J. Wang YN, et al. Among authors: saavedra je. J Am Chem Soc. 2005 Apr 20;127(15):5388-95. doi: 10.1021/ja042258l. J Am Chem Soc. 2005. PMID: 15826177

4

Diazeniumdiolate ions as leaving groups in anomeric displacement reactions: a protection-deprotection strategy for ionic diazeniumdiolates.

Showalter BM, Reynolds MM, Valdez CA, Saavedra JE, Davies KM, Klose JR, Chmurny GN, Citro ML, Barchi JJ Jr, Merz SI, Meyerhoff ME, Keefer LK. Showalter BM, et al. Among authors: saavedra je. J Am Chem Soc. 2005 Oct 19;127(41):14188-9. doi: 10.1021/ja054510a. J Am Chem Soc. 2005. PMID: 16218605

5

Nitric oxide prodrugs: diazeniumdiolate anions of hindered secondary amines.

Chakrapani H, Showalter BM, Citro ML, Keefer LK, Saavedra JE. Chakrapani H, et al. Among authors: saavedra je. Org Lett. 2007 Oct 25;9(22):4551-4. doi: 10.1021/ol7019636. Epub 2007 Oct 5. Org Lett. 2007. PMID: 17918856

6

Cell-permeable esters of diazeniumdiolate-based nitric oxide prodrugs.

Chakrapani H, Maciag AE, Citro ML, Keefer LK, Saavedra JE. Chakrapani H, et al. Among authors: saavedra je. Org Lett. 2008 Nov 20;10(22):5155-8. doi: 10.1021/ol8020989. Epub 2008 Oct 29. Org Lett. 2008. PMID: 18956868 Free PMC article.

7

HNO and NO release from a primary amine-based diazeniumdiolate as a function of pH.

Salmon DJ, Torres de Holding CL, Thomas L, Peterson KV, Goodman GP, Saavedra JE, Srinivasan A, Davies KM, Keefer LK, Miranda KM. Salmon DJ, et al. Among authors: saavedra je. Inorg Chem. 2011 Apr 18;50(8):3262-70. doi: 10.1021/ic101736e. Epub 2011 Mar 15. Inorg Chem. 2011. PMID: 21405089 Free PMC article.

8

Novel protection-deprotection strategies in diazeniumdiolate chemistry: synthesis of V-IPA/NO.

Nandurdikar RS, Keefer LK, Saavedra JE. Nandurdikar RS, et al. Among authors: saavedra je. Chem Commun (Camb). 2011 Jun 21;47(23):6710-2. doi: 10.1039/c1cc12130h. Epub 2011 May 10. Chem Commun (Camb). 2011. PMID: 21556407 Free PMC article.

9

Enzymatic generation of the NO/HNO-releasing IPA/NO anion at controlled rates in physiological media using β-galactosidase.

Holland RJ, Paulisch R, Cao Z, Keefer LK, Saavedra JE, Donzelli S. Holland RJ, et al. Among authors: saavedra je. Nitric Oxide. 2013 Nov 30;35:131-6. doi: 10.1016/j.niox.2013.10.003. Epub 2013 Oct 11. Nitric Oxide. 2013. PMID: 24126017 Free PMC article.

10

Injectable formulation of disodium 1-[2-(carboxylato)pyrrolidin-1-yl]diazen-1-ium-1,2-diolate (PROLI/NO), an ultrafast nitric oxide donor prodrug.

Waterhouse DJ, Saavedra JE, Davies KM, Citro ML, Xu X, Powell DA, Grimes GJ, Potti GK, Keefer LK. Waterhouse DJ, et al. Among authors: saavedra je. J Pharm Sci. 2006 Jan;95(1):108-15. doi: 10.1002/jps.20486. J Pharm Sci. 2006. PMID: 16315224

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