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The Shc locus regulates insulin signaling and adiposity in mammals.
Tomilov AA, Ramsey JJ, Hagopian K, Giorgio M, Kim KM, Lam A, Migliaccio E, Lloyd KC, Berniakovich I, Prolla TA, Pelicci P, Cortopassi GA. Tomilov AA, et al. Among authors: hagopian k. Aging Cell. 2011 Feb;10(1):55-65. doi: 10.1111/j.1474-9726.2010.00641.x. Epub 2010 Nov 15. Aging Cell. 2011. PMID: 21040401 Free PMC article.
Decreased superoxide production in macrophages of long-lived p66Shc knock-out mice.
Tomilov AA, Bicocca V, Schoenfeld RA, Giorgio M, Migliaccio E, Ramsey JJ, Hagopian K, Pelicci PG, Cortopassi GA. Tomilov AA, et al. Among authors: hagopian k. J Biol Chem. 2010 Jan 8;285(2):1153-65. doi: 10.1074/jbc.M109.017491. Epub 2009 Nov 5. J Biol Chem. 2010. PMID: 19892704 Free PMC article.
The p66Shc knocked out mice are short lived under natural condition.
Giorgio M, Berry A, Berniakovich I, Poletaeva I, Trinei M, Stendardo M, Hagopian K, Ramsey JJ, Cortopassi G, Migliaccio E, Nötzli S, Amrein I, Lipp HP, Cirulli F, Pelicci PG. Giorgio M, et al. Among authors: hagopian k. Aging Cell. 2012 Feb;11(1):162-8. doi: 10.1111/j.1474-9726.2011.00770.x. Epub 2011 Dec 28. Aging Cell. 2012. PMID: 22081964 Free article.
The influence of Shc proteins on life span in mice.
Ramsey JJ, Tran D, Giorgio M, Griffey SM, Koehne A, Laing ST, Taylor SL, Kim K, Cortopassi GA, Lloyd KC, Hagopian K, Tomilov AA, Migliaccio E, Pelicci PG, McDonald RB. Ramsey JJ, et al. Among authors: hagopian k. J Gerontol A Biol Sci Med Sci. 2014 Oct;69(10):1177-85. doi: 10.1093/gerona/glt198. Epub 2013 Dec 14. J Gerontol A Biol Sci Med Sci. 2014. PMID: 24336818 Free PMC article.
Shc depletion stimulates brown fat activity in vivo and in vitro.
Tomilov A, Bettaieb A, Kim K, Sahdeo S, Tomilova N, Lam A, Hagopian K, Connell M, Fong J, Rowland D, Griffey S, Ramsey J, Haj F, Cortopassi G. Tomilov A, et al. Among authors: hagopian k. Aging Cell. 2014 Dec;13(6):1049-58. doi: 10.1111/acel.12267. Epub 2014 Sep 26. Aging Cell. 2014. PMID: 25257068 Free PMC article.
p46Shc Inhibits Thiolase and Lipid Oxidation in Mitochondria.
Tomilov A, Tomilova N, Shan Y, Hagopian K, Bettaieb A, Kim K, Pelicci PG, Haj F, Ramsey J, Cortopassi G. Tomilov A, et al. Among authors: hagopian k. J Biol Chem. 2016 Jun 10;291(24):12575-12585. doi: 10.1074/jbc.M115.695577. Epub 2016 Apr 8. J Biol Chem. 2016. PMID: 27059956 Free PMC article.
45 results