Niesen FH - Search Results

1

High-affinity inhibitors of human NAD-dependent 15-hydroxyprostaglandin dehydrogenase: mechanisms of inhibition and structure-activity relationships.

Niesen FH, Schultz L, Jadhav A, Bhatia C, Guo K, Maloney DJ, Pilka ES, Wang M, Oppermann U, Heightman TD, Simeonov A. Niesen FH, et al. PLoS One. 2010 Nov 2;5(11):e13719. doi: 10.1371/journal.pone.0013719. PLoS One. 2010. PMID: 21072165 Free PMC article.

2

Structural basis for substrate specificity in human monomeric carbonyl reductases.

Pilka ES, Niesen FH, Lee WH, El-Hawari Y, Dunford JE, Kochan G, Wsol V, Martin HJ, Maser E, Oppermann U. Pilka ES, et al. Among authors: niesen fh. PLoS One. 2009 Oct 20;4(10):e7113. doi: 10.1371/journal.pone.0007113. PLoS One. 2009. PMID: 19841672 Free PMC article.

3

Discovery of a potent and selective inhibitor for human carbonyl reductase 1 from propionate scanning applied to the macrolide zearalenone.

Zimmermann TJ, Niesen FH, Pilka ES, Knapp S, Oppermann U, Maier ME. Zimmermann TJ, et al. Among authors: niesen fh. Bioorg Med Chem. 2009 Jan 15;17(2):530-6. doi: 10.1016/j.bmc.2008.11.076. Epub 2008 Dec 6. Bioorg Med Chem. 2009. PMID: 19097799

4

Kinase domain insertions define distinct roles of CLK kinases in SR protein phosphorylation.

Bullock AN, Das S, Debreczeni JE, Rellos P, Fedorov O, Niesen FH, Guo K, Papagrigoriou E, Amos AL, Cho S, Turk BE, Ghosh G, Knapp S. Bullock AN, et al. Among authors: niesen fh. Structure. 2009 Mar 11;17(3):352-62. doi: 10.1016/j.str.2008.12.023. Structure. 2009. PMID: 19278650 Free PMC article.

5

The scientific impact of the Structural Genomics Consortium: a protein family and ligand-centered approach to medically-relevant human proteins.

Gileadi O, Knapp S, Lee WH, Marsden BD, Müller S, Niesen FH, Kavanagh KL, Ball LJ, von Delft F, Doyle DA, Oppermann UC, Sundström M. Gileadi O, et al. Among authors: niesen fh. J Struct Funct Genomics. 2007 Sep;8(2-3):107-19. doi: 10.1007/s10969-007-9027-2. Epub 2007 Oct 12. J Struct Funct Genomics. 2007. PMID: 17932789 Free PMC article. Review.

6

Structure of the CaMKIIdelta/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation.

Rellos P, Pike AC, Niesen FH, Salah E, Lee WH, von Delft F, Knapp S. Rellos P, et al. Among authors: niesen fh. PLoS Biol. 2010 Jul 27;8(7):e1000426. doi: 10.1371/journal.pbio.1000426. PLoS Biol. 2010. PMID: 20668654 Free PMC article.

7

Activation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sites.

Pike AC, Rellos P, Niesen FH, Turnbull A, Oliver AW, Parker SA, Turk BE, Pearl LH, Knapp S. Pike AC, et al. Among authors: niesen fh. EMBO J. 2008 Feb 20;27(4):704-14. doi: 10.1038/emboj.2008.8. Epub 2008 Jan 31. EMBO J. 2008. PMID: 18239682 Free PMC article.

8

Thermolability of mutant MMACHC protein in the vitamin B12-responsive cblC disorder.

Froese DS, Healy S, McDonald M, Kochan G, Oppermann U, Niesen FH, Gravel RA. Froese DS, et al. Among authors: niesen fh. Mol Genet Metab. 2010 May;100(1):29-36. doi: 10.1016/j.ymgme.2010.02.005. Epub 2010 Feb 15. Mol Genet Metab. 2010. PMID: 20219402 Free PMC article.

9

Structure of dystrophia myotonica protein kinase.

Elkins JM, Amos A, Niesen FH, Pike AC, Fedorov O, Knapp S. Elkins JM, et al. Among authors: niesen fh. Protein Sci. 2009 Apr;18(4):782-91. doi: 10.1002/pro.82. Protein Sci. 2009. PMID: 19309729 Free PMC article.

10

Kinase inhibitor selectivity profiling using differential scanning fluorimetry.

Fedorov O, Niesen FH, Knapp S. Fedorov O, et al. Among authors: niesen fh. Methods Mol Biol. 2012;795:109-18. doi: 10.1007/978-1-61779-337-0_7. Methods Mol Biol. 2012. PMID: 21960218

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